Intramuscular vs SubQutaneous Injections for Testosterone

[tareload]

@tareload

What they do see is presumably a trough TT value difference and hence incorrectly conclude that SQ is superior or end up with nutty claim that 80 mg of SQ is equivalent to 100 mg IM. They miss that their peak TT was higher on IM and think they got shortchanged compared to SQ based on single time point (presumably the usual trough measurement).

100 mg/week of TC IM vs SQ

IM modeled as 4.5 day elimination half life and 8 hr absorption half life
SQ modeled as 8 day elimination half life and 16 hr absorption half life

E7D injections and typical clearance volume…

IM is orange and SQ is blue.

If you were only looking at trough TT value then you might mistakenly conclude you are getting better results with SQ.

Here’s the stats:

IM left / SQ right

Trough SQ / Trough IM = 1.28

Going back to above claim:

@TC_Luoma

80 mg of sub-q T might equal 100 mg of IM testosterone.

100 / 80 = 1.25

Mean TT on either protocol after reaching stable temporal profiles is ~ 1000 ng/dl.

@Chris_Shugart

Just a quick personal experience here: after a couple of years of IM TRT, I switched to sub-Q and my testosterone tests consistently came back higher.

TT tested at trough? Important to always define when your TT was tested in relation to injection timepoint if you want to make sense of any relative change in protocol.