for your friend...
and no info about him...
If younger and had secondary hypo, then hCG might be creating a significant amount of T
Some have an exaggerated amount of testicular T-->E2 when using hCG and anastrozole [cannot | will not] control that
The above two points would be self-consistent.
read the advice for new guys sticky
read the protocol for injections sticky
don't ask what it wrong when things deviate greatly from recommendations, he should try the standard protocol.
His poor response to 20% T cream suggests possible hypothyroidism, but this is nuts, get him on the forum after he reads the above stickies, he will need copies of all of his labs and post ranges as well.
T is 200mg/ml in both cases? He is confused about what volumes to inject?