“Insulin sensitivity” is a term that gets thrown around WAAAAY too often in the bodybuilding world, and people seem to have only a vague concept of what it means.
Right now, the research is equivocal as to whether ALA will stimulate glucose uptake on its own or only in the presence of insulin.
Check out the literature and you’ll see that insulin signaling is equally stimulated by ALA in isolated adipocytes. This model is all we have, which shows the lack of info we really have on this supplement.
[quote]The Mage wrote:
Now I could swear that ALA only increased the insulin sensitivity of muscle.[/quote]
Right now, studies on non diabetics are all but non existent. If it worked like metformin and wasn’t selective in its effects, then its use would seem to be contraindicated.
…though a minor effect, and not effective in non-diabetic patients.[/quote]
Extrapolating the effects ALA in diabetics to healthy people is like doing so with cancer drugs in people who don’t have cancer. In other words it doesn’t mean anything.
C’mon dude, did you really just say that? That’s scary. Especially when we know so little about a topic. BTW-What does “bad” mean, and why would JB have info that no one else on the planet has?
Allow me to reafirm my position, that we just don’t know enough about ALA to state that it definitively hinders fat loss/maintainence, but so far, the small clues suggest that it is.
As always, I’m just trying to give people the info from which to make objective opinions.
Phill and Mage, thanks for the info, you guys are always helpful contributors to a discussion!