Basically, just get in the gym and lift crazy hard. A push/pull split or an upper body/lower body split where you're hitting every major muscle group two times a week will work wonders. It doesn't really matter if you go high reps or low reps as long as you're pushing yourself hard for an hour a day, 4-5x week. Do exercises you enjoy to keep your motivation level high.
Once you start making progress and dropping body fat, you can start getting more specific about the little things. Isolation work isn't really necessary at this point. Focus on big compound lifts (working multiple muscle groups at the same time-- bench, squat, deadlift, push press, kettle bell swings, leg presses, lunges, dips, pull ups, rows, etc) until you get a good solid base.
Don't skip core work too. Just because you can't see your abs doesn't mean they don't count. They're super important for proper form on all of your big lifts.