I used to get B-12 jell in single-dose packs that you would squirt up your nose to be absorbed via capillaries or whatever. I noticed a boost the first few times I took it and then it stopped. I assume I just filled whatever deficit I had been carrying and it stopped being noticeable. The sublingual B-12 irritated the bottom of my tongue. Pills do me no good as I had a good 2 feet of small intestine removed where B-12 is supposed to be absorbed(around the ileum). My doc will give me an occasional injection of it, but for some reason he doesn't seem to like doing this.