No need for injections. She can get compounded testosterone, bi-est and progesterone creams.
Progesterone is extremely important.
Please post her thyroid labs with ranges. "OK" is meaning less. If OK, why was she taking thyroid meds.
If she has not been using iodized salt long term, she is iodine deficient.
Thyroid problems cause fat gain and make fat loss difficult or impossible.
hCG will not work, here ovaries failed.
Weight gain with T could be recovery of muscle mass.
She should have a mammogram before starting estrogens.
Hypothyroidism or low thyroid function can cause skin changes that make absorption of transdermal hormones difficult.