Your serum T levels dictate anastrozole needs. Normal responders need ~ 1mg anastrozole for ever 100mg T ester. Your serum T levels are proportional to your T dosing.
Anastrozole is a competitive drug and there is a linear relationship for sane dosing.
A few guys are T hypermetabolizers who need ~3x T dosing and the above rule of thumb obviously would not apply.
E2 labs are needed to refine dosing.
If on T+anastrozole you get E2=30pg/ml and target is E2=22pg/ml, you would modify dose by a factor of current/target = 30/22. This same method would apply if E2 was low and the calculation would reduce the dose.
E2=22pg/ml seems optimal for: mood, energy, fat loss and patterns, libido etc. A few guys need higher E2 to feel right, seems like they are wired differently which is probably differences in gene expression and enzyme coding variations [which we all have].
There is no way to know in advance if one is:
- needing more E2 than other guys
- is a T hyper metabolizer
- anastrozole over-responder
- vulnerable to damage from 5-alpha reductase inhibitors [hair loss drugs] or other zeno-testosterones
- freely converts DHEA-->E2 in the adrenals
- SERMs not protecting nipples or resolving gyno
- low dose hCG promoting high T-->E2 in the testes
- feeling bad with hCG