Don’t want to hijack the thread, but are you saying that ALL men should take hCG when they start TRT, KSman? And can you provide a link to an article(s) explaining the E2 sweet spot of 22pg/ml. I need to be able to explain to my own doc, because he thinks there is no “too low” for men when it comes to e2.[/quote]
You doctor really has no idea about the role of estrogens.
I think that I first saw this E2=22pg/ml recommendation somewhere at lef.org, but it has been a long time and many others about the net have repeated this. From my own experience and the shared experiences of many other guys on this site and others and by PMs, I know that landing there from higher levels makes guys feel a lot better and really improves libido. E2=22pg/ml seems to be libido optimal. Low levels of E2 can kill libido, create ED, one feels like crap, joints ache, mood problems or depression. Would some feel better at E2=15? Perhaps, but most might not feel as good.
Tell your doc to take 1mg Arimidex per day for a month and then he can make up his own mind. Estrogens are essential for proper brain function.
We know that anastrozole over-responders find out that status when there E2 crashes into single digits or undetectable levels. They feel horrible!
We need E2 for emotional integrity. Many might feel emotionally dry at E2=22pg/ml. One can be detached and analytical, which are classic normal male traits. As males develop in the womb and as infants, then again in adolescence, levels of testosterone create sexual pursuit regions in the brain that are 2.5 times larger than females, and the parts of the brain that are involved in communication, verbal expression, emotions and social connection are significantly killed off by testosterone. Your life is run by hormones. The male brain is a modification of the female brain. Estrogens are absolutely essential for proper brain function. There is aromatase in the brain to make essential estrogens locally there as well. Aromatase inhibitors can affect that as well.