T Nation

How to Increase E2 Without Increasing Test Dosage/Decreasing Frequency?



When I don’t take the arimidex, e2 on it’s own doesn’t increase enough in order to possibly feel a sex drive.

Does anyone know how to increase e2 WITHOUT increasing test dose or decreasing frequency? Please just help me answer that.


DHEA is known to raise E2 in men and T in women.
You have stated you can’t buy HCG so that is out. I know of nothing else. You don’t supplement with DIM do you?


I have supplemented with dim prior but not in awhile.

DHEA is about the only thing I think I could try as well. Just wondered what others do that don’t produce enough estrogen from aromatase. I am pretty lean but don’t want to get fatter just to make estrogen.


@roscoe88 how often do you change your protocol? My advice is to stop everything but testosterone for six weeks and reassess.


I’ve run this protocol: 50mg e3d for longer than 6 months and e2 fell at 27pm/ml with tt 860. No ai.

Yes, that’s low e2 but I want to try to lower it a tad more to see if it affects sex drive positively. That why I’ve introduced a little arimidex.

If I don’t get into a sweet spot, etc I’m going to try going the other way. But I’m doing so, I’ll need to raise e2 and keep test the same.


@roscoe88 my personal opinion is to stay the fuck away from an AI with that e level. Libido has many layers to it besides estrogen. You are doing to crash your estrogen playing with an AI. What else is going on in life for you? Stress, sleep, etc.


I just quit coffee and all caffeine about a week ago due to always being such a light sleeper. I work as a lawyer, so that means low pay and a ton of stress (i.e. hate my job).

I was diagnosed secondary hypo a few years back, but thyroid came back ok and no tumor in pituitary.

I haven’t had a sex drive at all since I was about 20. I’m now 40. It’s been HELL on relationships.

When I first started TRT, my first protocol was 300mg test every other week. I did get glimpses of libido then, presumably from higher e2 levels.

I just think I need to get my t/e ratio closer to 20%, meaning keep my test around 860 (which it is now) but increasing e2.

Maybe i’ll lay off the “low e2” experiment and try going the other way, adding maybe a low dose of dhea to increase e2 more than my body had the ability to aromatize.


Side note: I had my preg and dheas tested recently.

Preg was way below normal, and deahs was mid range.


Hi Roscoe, I lost my libido for about 15 years, I’m a few years older than you, it took a TT trough of over 1100 Free T 33 labcorp top of range 18. before my libido came back balls to the wall. I have since throttled my TT back to 975 so my wife has a break, haha


I vote stopping the AI too. I was tinkering with arimidex with the same goals and crashed my E prob 5-6 times in a year. No AI now for 8 months and finally feeling good again.

What’s “normal” AI dose for you anyway? Mg and frequency?


Thanks for the vote of confidence.

I was (didn’t take last dose) .50mg e3d. Started at a lower dose and ramped up.

Not sure where it’s gone. I get good morning and night wood, but with sex it’s hard to maintain as there’s just no libido.

I actually think test controls the ability to get erection but is only triggered by libido, which comes from estrogen.

I may try a higher dose to get tt up a bit. It’s all trial and error. I didn’t take my scheduled arimidex yesterday either.



What was your protocol when you had that good libido?


When my hormones were not in check I needed continuous physical and visual stimulation to get erection. So you not alone v


Exactly. Like that warm feeling that takes over your body when you’re with a girl, etc. is lacking. There is a litttttleeee blood flow, but not much.

Like I explained, I think test (at the right level) says to the body "ok, all of the orchestra is here ready to go… we just need the conductor (estrogen in the right amount) .


I have been with Defy for the last two years .25(50mg) M/W/F so 150mg/wk, 400iu HCG 2xWk, AI anastrozole .125mg 3 times a week
After two months my E2 was 28 My shgb is 25 Your shgb matters more than you might think. What was yours again?


My shbg ranges from 23-28 or so.

I may push tt up and see how I respond.


Just remember to stay on a protocol for at least 6 weeks to see how you feel. If you keep changing, you make it extremely difficult dial in.


I’m with Charles12. Your first experiment is to get your E2 down to the low 20’s and see if your libido comes back. That is a very good test but .5mg x2 or x3 of anastrozole is way too much to get your current lvl down to 22. You will crash your E2 like everyone has posted and if that happens libido will be your last concern.

You really need to hold one course and do mini blood tests.


So I should hold my ai dose for 6 weeks straight too without adjusting?

What dose would you think would get me to 22 from 27?


Since you measured the 27 and if you have been taking your AI at 1 to 1.5mg/wk you could already be there or much lower. Anastrozole is really powerful shit. With your SHGB and current T cyp amount I would not do more that .25mg every 10 days and that could still be too much.

Trying to adjust an E2 by 5 pg/mL is impossible. Our hormones fluxuate way too much to be that accurate. Hell the lab errors could be 5 pg/ml. TT FT E2 are moving targets and when you get a blood test you are getting a snap shot of the general area your levels are in and that is the best you are going to get.