T Nation

How Should I Divide Arimidex Dose?

I am on 200mg per week of T Cyp. intermuscular. I’m taking 2 1mg arimidex per week. My question is, how should I divide it up? Just take 1 pill at a time or divide each of them in half and take .5 mg EOD or so? I don’t have any lab numbers for E2 yet so I don’t know where I am, that will happen at the end of the month. I realize the accepted way here is to stick SC twice per week, I will talk with him about that when I go in to go over labs.

Your starting dose is too high. You should be at 100mg/week and testing after 6 weeks to see T levels. 200mg will likely put you over top range of normalcy and lead to complications long term. As for the AI, you should divide it into two doses minimum over the week. I would think 2mg a week is probably a little too much. Even though 1mg per 100mg test is the norm, the higher dosages usually don’t dictate increasing Arimadex linearly but you can test after 6 weeks to see. I’m guessing T too high and E too low as your doses but we will see.

I’m guessing my T dose is high as well, but will find out soon, last time I had blood done I was top end of the range but he had me on a loading dose. He didn’t check my E2 last time, I had to ask to be put on the AI. I’ve just been taking 1mg twice a week but was wondering if I should break it up more throughout the week. Thanks.
Total T 1390 (348-1197)
Free 35.3 (8.7-25.1)

How long after injection did you get those results? Your results are based on one injection per week correct?

Yes, 1 per week. Injection was on thursday, blood draw was Monday. At that point I was only on T. I am now also doing EOD 250 HCG and also Arimidex as I explained. Thinking I should cut down the Arimidex dose to 1.5 per week. I’m sure it will need further adjusting if I go to SC 2x per week, also will probably lower the dose.

If your T is that high 4 days after injection then you are probably on to high of a dose. KSman would be better to comment on your AI dose. I would go with the 1.5mg if it were me but I have a suspicion he would differ in opinion. I am sensitive to AIs though as I mentioned so I have had bad experiences being overmedicated on AI.

I will stick to the question in general. Things specific to your case should be kept in one of your other threads so you are not spread out so much that context is lost.

Anastrozole is competitive to T. Injecting T once a week leads to large changes in serum FT [or bio-T], so FT–>E2 production rates are changing. If FT is changing and serum levels of anastrozole are not, dose will not be optimal.

Inject T twice a week and take anastrozole at that time. Then FT and anastrozole levels will roughly rise and fall together. Consider subq T injections for smoother levels with #29 1/2" 0.5ml insulin syringes.

You may need to switch to an anastrozole solution, 1mg/ml in vodka, to allow for arbitrary dosing amounts to get near E2=22pg/ml - 80 pmol/L

As I mentioned, I plan on talking to my Dr. about letting me switch to subq, until then, I’m wondering how I should divide up my dose of adex.

Inject T twice a week and take anastrozole at that time.

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