Why though? You’d expect DHT to be elevated just as you’d expect E to be elevated in correlation to having T 10x the top of the ref range… there’s a certain benefit to keeping the body within it’s natural balance regarding hormonal conversion during these times
What recreational drugs… using coke on AAS is COMPLETELY idiotic (no offence if this is you)… statistically the risk of SCD during the first 60 minutes post cocaine administration is 24x that of a regular Joe, combine that with ethanol to form cocaetthylene which is 20x more cardiotoxic (roughly) comparative to coke alone… so 20x24… combine that with AAS who statistically have a 3x higher mortality rate compared to the general populace (3x risk of cardiomyopathy, atrial fibrillation etc over a period of only 10 years) so whist this isn’t an entirely accurate ideology to assume as other variables interact but… 20x24x3… The effects of which coke exert upon the cardiovascular system co-link with some of the effects AAS induce… making it the perfect heart attack drug while on
- both induce a net effect regarding vasoconstriction (coke being far more intense)
- both induce hypertension
- both enlarge the left ventricle through similar mechanisms barring direct myocardial injury mediated via AR binding… Im talking about cardiac enlargement induced by catecholamine release/overload (AAS unregulates sympathetic nervous system, increases sensitivity of beta adrenergic receptors and thus sensitivity to epinephrine and norepinephrine)… Cocaine does this acutely, to a far more extensive degree whilst AAS is chronic, systemic… coke also releases catecholamines in MASSIVE concentrations… induces myocardial ischemia (another mechanisms for coke induced cardiac fibrosis/heart enlargement)
- both facilitate pro arrhythmic effects (AAS through catecholamines/development of myocardial fibrosis/cardiac enlargement)… coke through all of the above + impaired calcium handling, blockade of potassium channels and more
PLEASE don’t use coke on cycle, it’s an incredibly dumb thing to do… and if you’re using coke… coke, AAS and booze is seriously asking for it… will you be fine if you do it once? Probably, but why take such a risk?
I’ve used my fair share of recreational drugs, I’ve done some STUPID things… but I’ve never used coke or MDMA (risk of pill contaminants, had I had access to pill testing and known what I had on one of the myriad of occasions offered the story might have been very different)… nor have I ever done something outright retarded like methamphetamine… I’m willing to have a VERY good time every now and then, but I won’t use coke… Stick to cannabis… in terms of overall ACUTE risk (barring the immense risk of addiction) you’d even be better off (in terms of the risk of… dropping dead) abusing opiate painkillers… used within a normal dosage range, you won’t OD (so long as whatever you have isn’t fentanyl laced)… and I’d NEVER recommend abusing painkillers, it’s moronic… but to put things into perspective, the effects of coke regarding proarrythmiac effect appears to be extensive regardless of dosage… with opiates/benzodiazepines respiratory depression is dose dependent (and it’s very hard, borderline impossible to overdose and induce fatal respiratory depression from benzodiazepines alone)… should clarify I don’t abuse painkillers… well… tried it ONCE (within a recreational context)… but that was a little while ago now… was an incredibly dumb thing to do. Have also abused benzodiazepines a few times… as in literally only a select few times… regarding trying to determine what effect they’d have regarding effect on social anxiety… I don’t have “social anxiety” anymore, as a matter of fact travelling and going out solo numerous times appears to have cured me of this… bad idea, quite a few bad decisions were made on those nights…
Not talking about addiction potential here, I’m thinking of acute lethality… just please… stay away from cocaine, even amphetamine (not the methylated counterpart) is safer… cocaine just isn’t safe, yet appears to be casually used within recreation among numerous cohorts… especially kids in Europe, which surprised me as these kids have NO idea what the overall level of risk actually is…
Second point, how much and how often do you drink? It’s one of the more harmful recreational drugs we have at our disposal…
I understand, we all make bad decisions… but within reason man… if you’re using coke on cycle you’re asking for trouble (I only keep mentioning this because I can’t hone in just how bad a coke + AAS combo is… if you want to snort/smoke coke, just don’t use AAS, the two are incredibly synergistic regarding how much harm they induce when used together).