When I'm OFF anabolics, 405 x 5 is 1 rep short of positive failure. Oftentimes I am not able to reach 5 reps each set depending on how good I feel on that particular training day; sometimes I can only get 4 or even just 3 on a really bad day (they happen alot more than any of us would like!)
I never subscribed to training to failure. Even before Chad Waterbury pointed out quite correctly that nervous system fatigue is our real enemy here, I knew I just couldn't recuperate from that style of training. All you HIT'ers out there go right ahead and call me a wimp.
So when I'm on anabolics, it usually takes me roughly 8 weeks to build up my reps to 10 from 5 if we are using my bench example. I know this is slow for some, but for me this is pretty much the fastest I can gain in strength.
Also, for me I never payed too much attention to tempo as that is still uncharted territory for me (see, even after training for so many years, even old farts like me have something new to try and experiment with in the future!). I'm more the slow lowering, explosive lift type of trainer where the slow lowering can actually be as slow as 3 seconds, then explode and lift the weight as fast as I can from the bottom.
Joint issues I would get if I increased the weights past, say in this case, the 405 mentioned would be elbow and shoulder issues. For me, it never fails to creep up and therefore I'm sort of forced to train this way. You might be different, and therefore you should really see how increasing the weights work for you.