T Nation

How Do They Make Steroids?


No, I don't mean mixing up powder and oil and heating it. I mean, what do they extract it from, or create it from, and the like?

I just got done reading an article in which a company called Syntex was organized to make steroids from Mexican yams, using the syntheses invented by Russell Marker, (maybe wild yam extract is not B.S. after all!) :stuck_out_tongue_winking_eye:

I have no chemical background, but this stuff is fun to read, so if anyone has any cool articles or books to suggest, let me in on it...


They squeeze Ronnie Coleman and collect what comes out.

Then combine that with Chuck Norris sweat.

Bam, instant steroids.


Hey! You stole my joke...I just didn't know if I wanted to go that far with extraction methods !!


(side effects may include bad aftertaste, upset stomach, and a hankering to watch gay porn)


Little oriental people.

Heh, but in all seriousness I know back in the day in Germany they found that the there was something in the sweet potato that was damn close to testosterone, after that it was just a matter of getting enough sweet potatoes, extracting that particular compound and working chemical magic on it.

I'm not 100% sure how they do it today.

I do belive the first experiements ever in the steriod field had to do with bull testes though.

Maybe that's what anaconda is all about?

Maybe Cy researched all the animal testicles in the world and found that anacondas had the highest concentration of testosterone. All that would be left to do is throw em in a blender and add in some nano-gel and bam!

Post ban anabolic goodness.

Plus how baddass would it be telling someone the secret to muscle gain is the testes of the biggest snake in the world! You'd have the perfect door to talk about your "anaconda" as well!


I'm sure they use a bunch of boring chemical reactions you don't want to know about to arrange rings of various sizes into bunches of rings of varyiing sizes and then use yet more boring reactions to add certain chemical groups in certain places.

If you want to get into specifics, take a couple semesters of organic chemistry and you'll know more about it then you ever wanted in your worst nightmare.


Well, even though that sounds sooooo exciting, can anyone recommend anything for those not in-the-know?


Just pick up any organic chemistry textbook, mine is "Organic Chemistry" by John McMurry. I can't suggest a biochem textbook yet, but I can find out if you really want to know.

A good primer if you're not "ready" for that yet is "Biochemisty Primer for Exercise Science" and I can't remember the author.


The author is Michael E. Houston, and from what I see, it's been reviewed excellently.

Have you read this edition? And if so, does is specifically deal with AAS, or mostly the turnover of proteins, krebs cycle, fatty acids, different roles of cellular ARN, etc?



"Steroids are characterized by a molecular structure of 17 carbon atoms arranged in four rings. In the parent structure (named gonane and referred to as the steroid nucleus), the carbon atoms are bonded to 28 hydrogen atoms. Steroids are important in biology, chemistry, and medicine. They include the sex hormones, adrenal cortical hormones, bile acids, sterols, anabolic agents, and oral contraceptives.

The steroid nucleus is three dimensional. Steroids vary from one another not only in the nature of the attached groups but also in the configuration of the steroid nucleus and the position of the groups. Small modifications in the molecular structures of steroids can produce remarkable differences in their biological activities. Chemists have isolated hundreds of steroids from plants and animals. Thousands more have been made by treating natural steroids chemically or by synthesis.

Organic solvents are used to isolate steroids from natural sources. Sterols, the most abundant of the steroids, are treated with an alkali and then extracted by means of water-immiscible solvents, such as hexane or ether. Highly purified steroids can be obtained in the laboratory by these methods. Commercially large amounts of steroids are usually purified by repeated crystallization from solvents.

In plants and animals, steroids appear to be biosynthesized by similar reactions, beginning with acetic acid, assisted by a type of enzyme. The isoprenoid hydrocarbon called squalene, which occurs widely in nature, is thought to be the starting material from which all steroids are made. Enzymatic transformation of squalene produces lanosterol in animals and cycloartenol in plants, which yield cholesterol in both animals and plants. Cholesterol is then converted to bile acids and steroid hormones in animals and to steroids such as alkaloids in plants.

The commercial and laboratory synthesis of steroids usually begins with a one-ring starting material such as quinone, upon which other rings are built. Total synthesis of steroids has proved commercially feasible, but it is often more practical to prepare them by modifying other steroids that are naturally abundant. Certain microbes can transform parts of the steroid molecule, and industrial steroids are often made by a combination of chemical and microbiological techniques.

All the sex hormones and corticosteroids, which originate in the adrenal cortex, are derived from one of the most widely occuring steroids--namely, cholesterol. Corticosteroids play an essential role in maintaining life through a variety of hormonal functions that help to balance the ionic composition of the body fluids. Bile acids, a type of steroid found in mammals, play a role in emulsifying fats during digestion.

Cholesterol, in addition to its role as a precursor of steroid hormones, is an important component of cell membrane. Unfortunately, in some persons excess serum cholesterol contributes to the formation of deposits on the arterial walls, which leads to atherosclerosis.

The first therapeutic use of steroids goes back to the 18th century when foxglove extracts were found to be beneficial for some heart conditions. The active ingredient in these preparations, digitalis, is still used today. It is a steroid glycoside, a molecule in which a steroid is linked to a sugar residue. Many plant steroids are cardiac glycosides, which in large doses can be fatal and may be used by the plant to ward off predatory insects. Some toads secrete steroid glycosides that may also act as a defense mechanism."


The book goes over DNA/RNA stuff and the metabolism of the carbs/fats/proteins. It's pretty basic for me (used it for a class a while back), but I guess it's a good primer, just as the title says.


Just run a google search on "Anthony Roberts" and "Testicles".


Damn Rainjack, LOL.


that was funny, but still, you guys need to figure your shit out


You just posted in another thread for some of us to stop hijacking. Now you are at it again. Do you think it is okay for you to get on here and do your own brand of hijacking by playing net nannie?


Hey, I have that McMurray book too. Damn good book

Biochemistry books aren't really going to be useful in assisting somebody to make steroids (if that's your goal). Just figure out how to isolate the core and alkalate or methylate (whatver is needed). I'm sure you can find experiments on GOOGLE or in journals.

Get a grad degree in organic chemistry or chemistry if you want to start a business with this.


Figure what out?