I agree about height being an important factor.
Personally I think that once you reach a certain size you have to begin to compromise in other "athletic" areas of your life, things like agility, the ability to sprint for a bus or climb a wall or go on a long hike without getting too winded.
I want to get as big as I can while having a minimal impact on these other areas, and I think for my height (6'2") 220lbs lean would be ideal. I don't intend on ever getting bigger than that myself, but I wouldn't call someone else who was bigger TOO big. Each to their own I say, get to whatever size makes you happy, though I really don't see the appeal of getting to a size where personal hygiene becomes a challenge.