High T, Perfect E2 - TRT a Complete Failure (1 Year) - Help!

Thyroid does not seem right. T3 is well below midrange, T4 a bit too. Low ferritin can interfere with T4–>T3 conversion. fT3 is the active hormone. Labs should have been TSH, fT3, fT4 and skip the uptake and index labs which are obsolete now that we have fT3 fT4 labs available.

Eval your overall thyroid function via last paragraph in this post.

Have you always used iodized salt? - needed to make thyroid hormones

What time of day was Cortisol=19.2 done?
Is there a lot of stress in your life? Illneses/inflammation chonic or acute, accidents?
Are your limbs thin? Body not?

IGF-1 is a better indicator of GH status than GH itself.
Level very high for your age and very high for those who need to inject GH.

Labs, please show:
RBC
MVC
hemoglobin
HTC hematocrit
AST/ALT
ferritin
serum iron = 54 38-169

Iron seems low.
Do you have digestive/GI problems or food sensitivities?
Heart burn?
Use heart burn medications? PPI’s?

Please read the stickies found here: About the T Replacement Category - #2 by KSman

  • advice for new guys
  • things that damage your hormones
  • protocol for injections
  • finding a TRT doc

Evaluate your overall thyroid function by checking oral body temperatures as per the thyroid basics sticky. Thyroid hormone fT3 is what gets the job done and it regulates mitochondrial activity, the source of ATP which is the universal currency of cellular energy. This is part of the body’s temperature control loop. This can get messed up if you are iodine deficient. In many countries, you need to be using iodized salt. Other countries add iodine to dairy or bread.