T Nation

High T Levels But TRT Doesn't Feel as Effective as It Used To. Labs Included


I’m 48, 180lbs, low body fat, work out 4 to 5 days per week. I’ve been on TRT for 4 years. When I first started, I went to a men’s health clinic and they tested me, My Test levels were in the low 200’s and they put me on 100ml once per week. I felt great…mood, energy, libido all through the roof. That lasted about a year and I had a regular visit with my doc and I explained that what was going on and she told me she is a hormone specialist and she could give me a much better level of care than the men’s clinic. I went along with it and she actually did. She recommended that I also use HCG and Anastrozole. This was about the time I found this forum as well. Since her protocol matched up with what is suggested here, I felt like I was in good hands.
We experimented with dosages of the HCG and the Testosterone eventually modifying my TRT to go with the standard protocol that is recommended here. I do 25ml of Test every Monday and Friday (equals 50ml or 100mg per week) and 1/10 ml (6 drops) of Anastrozole at time of T injection (I believe I’m an over responder). I also do 25ml of Hcg EOD. I think my most recent labs (taken on a Wednesday (close to ½ way between my T doses) look good although a tad bit high on the T. Problem is, I no longer wake up with morning wood and don’t have the same libido I use to have. No problems at all with ED, I just liked having a high libido. I also don’t feel quite as good as I did when I first started. So, I guess my question is after being on TRT for a while, dose the feeling of high energy, great mood and high libido sort of calm down or should I be considering a change in my doses or what? Obviously, my T levels are on the high side so I can’t believe it’s that?

Here are my labs:

The last one on a page by itself was:
SHBG 34.4 nmol/l 16.5 – 55.9


Sometime less is more, too much of anything is bad for you. Not everyone on earth is going to feel their best with high free hormones over the range. HCG might be the cause of lowered libido, some men feel great on it for awhile, then the benefits fade.

I’ve heard countless stories of men who at first feel amazing on HCG, then it starts making them feel worse. If you were a low SHBG guy I would tell you when FT is high, free E2 must also be high. Regular E2 sensitive can be misleading in regards to free E2 levels.


So would you suggest cutting back on HCG or to try cutting it out all together?


You need to lower test dosage anyway because your HCT is high, this already suggests you’re on too much test. Cut back test and keep the HCG for now, wait and see. You don’t want to go changing more than one thing at a time otherwise you won’t know what worked and what didn’t.

Small changes one thing at a time, labs every 6 weeks and note how you feel. Suggest 40mg twice weekly (80mg weekly).


My Hemoglobin and Hematocrit are both slightly elevated but I’m just about due to give blood so I’m guessing giving blood will correct that. Also my Cholesterol is high but I didn’t fast before the test (didn’t know they were testing cholesterol). Other than that, how do these labs look? Is my T actually too high or is that on the high end of where it should be? It looks to me like my Estradiol is about right and my Calcium Serum (?) seems high, which seems crazy because I don’t drink milk or take supplements other than multivitamin. My SHBG seems right in the middle of the range.


Humans aren’t numbers. Your labs look acceptable, but you gotta go by what you feel.