You likely won’t have anything wrong occur with you from using oxandrolone for 8 weeks. Literature shows (in sick people) it’s a relatively safe drug, it’s been used at 20-80mg/day for prolonged periods of time in HIV+ patients, and in children oxandrolone has been used to treat short stature (high and disproportionate ratio of anabolism to androgenicity, and the anabolic potential of AAS include stimulation of linear bone growth if growth plates aren’t already fused), in low doses (.1-.2mg/kg/day) in multiple trials oxandrolone has been shown to increase final predicted adult height.
The problem with oxandrolone is that it tends to trash you’re lipids (and 25mg will certainly do this), it’ll also suppress you’re HTPA, I believe 15mg/day shuts off about 50% of you’re natural T production (or was it 60%?) I don’t remember, so while 25mg won’t shut you down as hard as 25mg/day of test would, it’ll still suppress you… heavily, were talking about an 80-90% decline in test levels. However the decline is reversible, once you stop using, levels tend to go back to baseline.
Will oxandrolone lower you’re SHBG? Yes, because DHT has a very high binding affinity to DHT, oxandrolone is a DHT derivative, has a very strong binding to the AR and to SHBG. Legitimate oxandrolone is pretty strong stuff. However after you cease use of the oxandrolone, all hormonal parameters will creep back to baseline.
SHBG fluctuates, as does free and total T. From what I see, you have a high normal level of DHT, a high TT, low normal Free T… Do you have symptoms of low T? Because you’re problems may not be hormonal at all.
Hepatotoxicity can also be a concern with oxandrolone, however less so than other C17AA androgens as it is primarily really metabolised (uniquely of all other AAS) and thus nephrotoxicity is probably a bigger issue. You won’t get heart, liver disease from 8 wks at 25mg/day (high blood pressure is a concern), the chances of cancer is like 0.000000000001% at that duration and dose of use with monitoring of a doctor (of course those tiny odds are an exaggeration, I mean the chances of acquiring cancer in the next month regardless of oxandrolone is probs higher than 0,000000000001%)