Cortisol, Folate, Thyriod Stimulating Hormone, Free Thyroxine, Free T3, Follicle Stim. Hormone, Luteinising Hormone, Prolactin, Growth Hormone, B12 - were all within normal range.
When I asked my GP about SHBG, he said it was a problem but he didn’t know what could be done about it. I asked if it may implicate high estrogen inhibiting testosterone, he said maybe but he’d have to ask the lab if I was eligible for estrogen testing.
My knowledge of the mechanisms of SHBG is limited, but a cursory Google search brings up the drug Proviron (Mesterolone) as being used to reduce it. I want to learn about the implications of this, what causes high SHBG, and whether bringing it down may help my issues with libido and fatigue. I have never had any TRT. Thanks.
I also had high SHBG (62). The Dr. moved my T levels close to the top of the range and my SHBG came down as he said it would. (Higher T lowers SHBG) The high total T level and mid range SHBG gave me a big boost in Free T. So far I don’t seem to need an AI but you do want to keep an eye on the E2. E2 is a critical part of TRT. If you get you T levels fixed but your E2 is too high (or low) you will feel like shit. You can order your own blood tests on LEF.org and they are not too expensive.
I see you had a similar issue as me. My TT is within range however due to high SHBG(no known cause) FT is very low. TRT is what doc is gearing towards but finding mixed signals about exogenous T lowering SHBG.