There is a large debate over high estrogen being OK and not having an impact at all. Here is my personal experience with labs and symptom resolution.
To kick start this off a little background on me.
Started TRT using 50mg Twice weekly.
Labs on this protocol had me at:
106 PG/Ml Free T (46-226)
Ultra Sensitive E2 22 (<29)
Felt best on this protocol at the end towards trough… high E2 the culprit?? Read on
With these labs I upped dosage to 75 mg Twice weekly… felt good initially but after 4th dosage on new protocol immediately the day after began to feel like shit.
Here is what I felt:
Anxiety through the roof (drunk feeling)
Anxiety so bad penis remained contracted flaccid with little blood flow
Low penile sensitivity (harder to orgasm)
Non existent sex drive
Water retention (gained 5lbs)
Armed with this information I decided to have labs done the day after my 75mg injection and on Trough the day of the next injection
results are as follows:
196 Free T (46-226)
Ultra sensitive E2 64 (<29)
142 Free T (46-226)
Ultra sensitive E2 34 (<29)
Clearly the higher estrogen is the cause of all my symptoms because as soon as my estrogen lowers around TROUGH (estrogen decreased from 64 to 34) symptoms go away. Anxiety gone, penis sensitivity back, libido back, mood better, morning elections are harder as well. This is no coincidence
So @dbossa how is it that the higher estrogen has nothing to do with my symptoms? When my E2 is higher after injection I have symptoms that are replicated with each injection and the common denominator is higher E2 levels…
I always feel symptom resolution when E2 is lower and always feel worse when E2 is higher. Even on my 50 mg 2x weekly protocol. My E2 was 22 then but had to have been closer to 40 during peak (and that is when I felt anxiety, low libido) on the 100mg weekly protocol.