Im no expert as I only recently dipped my toes into the anastrozole pool. I had E2 come back high so am starting to dose .5mg twice a week at time of injection. I took a .375mg does on Wed and today is shot day. I think the does really depends on how you respond to it. Ive seen people say anywhere from .0125mg a week to 1mg a week. KSMan recommends 1mg a week divided in doses at time of shot: TRT: Protocol for Injections