It wasnt placebo. Absorption of anastrozole is rapid and maximum plasma concentrations typically occur within 2 hours of dosing under fasted conditions, longer if taken with food. You really should get a blood work snap shot of your e2 levels before introducing a new variable, but I’m sure you’re anxious for relief. Because of anastrazoles half life, I prefer every other day, smaller doses. As others mentioned, complete stabilization takes weeks since estrogen blood serum levels in men are the result of aromatization versus clearance rates barring exogenic sources and that pendulum takes time to settle.
If you start to feel like you’re peeing a lot, sleepy all the time, have chronic head aches in your forehead behind your eyes, less vascularity, low level depression, unusual cold in extremities, your e2 may have been driven too low.
Get follow up blood work in a month to see where your e2 is. Low e2 is less pleasant than high. Something to consider in our often “more is better” mindset, ie be careful with anastrozole.