From what I’ve gathered, pretty much everyone seems to agree that running Arimidex at .25-.5mg EOD for a typical 500mg/week of Test E cycle seems to be enough to prevent gyno and E2 related sides… However, KSman (one of the most knowledgeable guys on the site) recommends using a much larger dose: namely, 1mg/week for every 100mg of aromatizable drugs taken. For the cycle described above this approach would yield approx. 1.5mg EOD. He (KSman) argues that while .25-.5mg EOD may be enough to prevent gyno, that doesn’t mean that the dose is optimal. This reasoning sounds logical to me, especially considering that Arimidex is a self limiting drug that will only lower E2 to a degree (50% if I remember correctly).
This leads me to an additional question: if A-dex is self limiting, why is it is possible to lower E2 so much using it, that people suffer from low E" side effects like low libido, depression and joint problems when they take too much. This wouldn’t make much sense if the drug could only lower E2 by 50% max. Is it that all of these people suffering from low E2 while taking A-dex are over-responders?
I thank you all for your attention (and if KSman reads this, your contribution would really be appreciated).