Another thing I've read is swale saying that you should not do 5on 2off. Just take the total amount you want to use in a week and divide by 7. He favors consistent dosing.
I've also read from Hogg ...."we could just default to the Serono method and inject before bed. BUT THEN ENDOGENOUS GH SECRETIONS ARE SUPPRESSED RIGHT???? Yep, but they would be anyway. Your biggest natural secretion is at night...but you're going to be injecting more in one dosage than your body produces in an entire day and by Nandi's studies, there is no free lunch....you cant keep your endogenous release up while shotgunning 3-4x supraphysiological dosages of exogenous HGH. It just simply wont happen. Since you cant time your morning injection right unless you have the ability to get to your GH mid morning, I would inject 4iu at bedtime and call it done. If you can be home mid morning, I would wait until you burn off breakfast and then inject 2iu mid morning and 2iu at bedtime. If your meal/work/training schedule is psychotic like most working professionals, then you'll have to work with non-optimum administration and just deal with being hyperglycemic once or twice a day.
Here are some rules to keep in mind, if your glucose level is high and you administer GH, GH holds insulin at bay, leaving you hyperglycemic (relatively speaking). Once the GH metabolizes, insulin levels rise and burn the blood sugar. When your glucose level falls to 50%, GH levels rise to stop the insulin. This is not an optimum case, especially since while hyper, the HGH may cause your organs to feed on fats, and the fatty acid release will cause your organs to turn their back on glucose....meaning that you burn fat and then the excess sugar is stored as fat....errr, sort of like a round trip from Compton back to Compton....not good. Now, if you are not hyperglycemic and inject HGH, and your organs turn toward fats for energy, and then you eat say 1-2 hours later....essentially trying to ride the edge of hypoglycemia, you can avoid the accumulation of adipose tissue from post-metabolization hyperglycemia (edit - being hyper until the GH metabolizes and then when the insulin kicks in, your organs dont need the glucose) ....or so the theory might hold....
Errrr.....went too far, which is easy to do with this topic. Ace, just stick to the 4iu at bedtime and call it done.
As far as how many days on and how many days off, your bank account is what rules this variable.
I sincerely doubt anyone (that works for a living) does it perfect....its just too hard when you have commitments. "