KsMan: I believe Somatostatin is the hormone that regulates GH.
Somatostatin reduces GH release (brakes), GHRH increases GH release (gas). These things interplay to control the amount of IGF-1 in circulation. Higher IGF-1 leads to reduced GH secretion. IGF-1 is the major negative feedback signal. Cortisol also reduces GH secretion by acting on the Pituitary Somatotrophe (cells that secrete GH). Sex steriods increase GH. Carrying more fat reduces GH, so lower %BF will increase GH. Higher GH reduced fat. So we have an unstable situation. When you get fat, GH goes lower and that makes you fatter.
To quote AR: “Remember the negative feedback loop I always tell you about? Well, of course, your body has one which can stop the secretion of HGH, and it involves IGF. When your liver receives secretes IGF-1, it sends a message to both your Hypothalamus as well as your Pituitary to stop producing HGH.”
I would like to figure out the dose equivalents or cost effectiveness of Hexarelin, GHRP-6, IGF-1, HGH; mostly from the point if view of HRT. If GH is converted 1:1 in the liver, IGF-1/Lr3IGF-1 seems to be way too expensive.