T Nation

HGH Effects, Timing, Amount, Frequency

GH benefits:

GH effects carbohydrate, lipid, and protein metabolism; increases circulating levels of glucose, stimulates lipolysis to increase FFA, which in turn blocks glucose oxidation; and impairs both hepatic and peripheral insulin sensitivity, particularly in the muscle where glucose oxidation is reduced.

GH effects metabolism, it suppresses glucose uptake and glucose oxidation, and stimulates gluconeogenesis, glycogenesis, and lipolysis fat burning.

GH antagonises the action of insulin on peripheral tissues and thereby decreases glucose uptake and increases glucose production. Insulin levels increase to counterbalance the elevated glucose following GH administration. GH-induced lipolysis in the visceral tissues and later increased FFA interferes with insulin signaling pathways.

GH

Augments low GH from poor sleep
Increases skin tone
Builds muscle
Increases strength
Builds bones
Decreases fat

Symptoms of low GH:
GH-deprived state called somatopause.
Growth hormone decline at 25 years old and accelerating at 35.
It’s said that you loose 14% GH production per decade.
This also occurs acutely with poor sleep patterns.

  • Decrease muscle and strength
  • Increase fat especially around the waist
  • Changes in ‘good’ and ‘bad’ cholesterol.
  • Changes in circulation
  • Osteoporosis
  • Low energy levels and decreased stamina
  • Impaired concentration and memory.

Testing for low GH:

Insulin tolerance test. This involves giving an injection of insulin to the patient to lower the blood sugar level. During this stress reaction, the body normally GH. Failure to produce an adequate amount of GH in response to this insulin induced stress confirms GH deficiency. Serum IGF-I concentration is also used.

The normal range for GH level:

Males – 0.4 to 10 nanograms per mil (ng/mL), or 18 to 44 picomoles per L (pmol/L)
Females – 1 to 14 ng/mL, or 44 to 616 pmol/L
Children – 10 to 50 ng/mL, or 440 to 2200 pmol/L

GH is released in pulses. The size and duration of the pulses varies with time of day, age, and gender. This is why random GH measurements are rarely useful. A higher level may be normal if the blood was drawn during a pulse. A lower level may be normal if the blood was drawn around the end of a pulse. GH is most useful when measured as part of a stimulation or suppression test.

GH side effects:

Although GH therapy reduces visceral adiposity, improves dyslipidaemia, and metabolic disturbances, GH treatment elicits impaired fasting glucose and increased insulin resistance, particularly in obese patients. Because insulin resistance and glucose intolerance are linked to the risk of diabetes, there is due concern that patients with metabolic disorders may develop diabetes following GH treatment. This is why a low card option is ideal.

Other possible issues;
Fluid retention, Swelling in the arms and legs (edema)
Joint discomfort, nerve and or muscle pain
Increase blood sugar and insulin resistance.
Type 2 diabetes.
Carpal tunnel syndrome.
Gynecomastia
Increased risk of certain cancers.
Distended belly
Numbness and tingling of the skin
High cholesterol levels

Dosage, frequency of HGH:

Understanding the bodies peak GH pulse release helps you understand when to best take GH. 4pm and midnight seem to be optimal. The body pulses GH after physical muscle stress and aerobic training to repair and recover muscle tissue.

GH is stimulated immediately after a workout and decreases within 60min.

So HGH should be injected right after a workout. The body also pulses GH during sleep for muscle repair and recovery and avoid elevated blood glucose levels during this time. Post workout protein should be low sugar. Data demonstrate however that heavy resistance exercise in the “late afternoon” decreased overnight maximum hGH concentrations. So maybe we should keep our training in the early afternoon.

https://journals.physiology.org/doi/pdf/10.1152/jappl.2001.91.1.163

Peak Time of GH Pulses:
4-6pm (4-6ug/L)
Midnight - 2am (8-17ug/L)

So ideally, you may want to workout between 2-5pm to catch the physiologic pulse rhythm and be in bed before midnight.

To minimize side-effects but taking effective amount to have impact,

4iu per day split into 2iu injections is ideal.

Too high a dose too frequently injection may produce HGH resistance. It’s very natural for the body to block high levels of any physiological event.

We know this from a growing number of insulin-resistant pre-diabetes epidemic we now see unfolding in modern society due to frequent over-feeding, creating high levels of hyperinsulinemia.

Injected in the late evening to mimic the body’s natural growth hormone secretion cycle.

Injected 5 days per week, with two days off. This is also more cost effective!

Research shows HGH replacement therapy, injecting HGH 5 or more days per week may reduce some of its benefits.

Addendum: there’s research out there that shows doubling the dose and taking it eod leads to approximately the same IGF-1 numbers and makes the time coming off easier. Despite the short half life the time that GH is effective is much longer than most people think.

I think I saw that too. Science approach varies but always good to discuss. :syringe: :thinking: