hfcs is basically table sugar with a little more fructose. The problem I have is with the fructose- the liver converts fructose directly to fatty acids which will then most likely be stored as blubber. The one exception to fructose being converted to fatty acids would be when liver glycogen is depleted then I'm pretty sure the liver can use fructose to replenish it's glycogen.
I'm pretty sure you knew all of that though, given some of your posts that i've read. but anyway, hfcs is no worse than sucrose.
Relating to American obesity I think people should start thinking about leptin resistance and certain things that can cause leptin resistance like lectins which can probably be found in hfcs.