For the Westside for Skinny Bastards routine, on the ME day, if you're using box squats, you will be working your way up to a 3-5 rep max. For example, it will be something like this.
Warm up set-45lbs (Might want to have a few more of these sets.)
and so on. Work up to a final set of your 3-5 rep max. The idea is not to work to failure (aka 1 rep max)
If you are looking for more hypertrophy, generally the idea is to have more sets (higher volume) but that depends on how you can split up your 'jumps' on the different workloads you'll be using. Also, if you're looking for strength for sports, then by all means perform all your movements in an explosive manner. In sports, you never really execute any movement that is not explosive, well, at least for sports like Basketball, football etc.