hi all first time poster long time reader
i am 40 years old and recently started trt. my labs and protocol as follows
PRE TRT (27 Feb 16)
Oestrogen 60 pmol/L (range <160)
Total Test 15.7 nmol/L (range 9.9 - 27.8)
SHBG = 28
Free Test = 350 pmol/L (range 170-670)
After 8 weeks of Testosterone Enanthate Injections IM - 125mg every 5 days (which is 25mg day) with AI (Anastrozole) at 1mg every 3 days. I found that my oestrogen felt too high (sensitive nipples and other perceived symptoms) so i moved the AI to 1mg ED for 10 days and had bloods done at the end of 8 weeks and these were the results. You can see that I am clearly not an overesponder to anastrozole. Note the below test was taken 5 days after my test shot (i.e. the day I was due for my next shot so as low as I would be in the 5 day cycle)
Oestrogen 49 pmol/L (range <160). Note that this equates to 13 pg/ml (which I understand is lower than optimal)
Total Test 35.8 nmol/L (range 9.9 - 27.8)
SHBG = 24
Free Test = 1071 pmol/L (range 170-670)
my problem after 8 weeks was I wasn’t happy with nut shrinkage so wanted hcg. Also lipid profile. i have always had high cholesterol (genetic) from the age of 20 it was been at least 6 (5.8 being upper range). but my hdl/ldl ratio is very good so doctors were not concerned. 8 weeks of anastrozole at the above dose my HDL was smashed lower by 30% and LDL increased by 30% ! so my theory was I need higher amounts of Anastrazole than would be healthy long term so that is not sustainable
Took a break for a month then wanted to go back on trt and my doc said I should lower my test dose. we moved this to 125mg every 7 days (so 17.85mg a day which is a 30% reduction from previous dose) still IM. also we added HCG at 250iu (2 days before and day before my weekly test injection). so 500iu in total a week. after 6 weeks I had bloods done again. I note that the HCG has kept my nut size so i will definitely stay on the HCG!. I stayed with the original arimidex profile of 1mg twice a week (and every now and then I would throw in a bit more when the nipples were sensitive). after 5 weeks I got a box of aromasin as i understand it is not as harsh on lipid profile. I took 25mg a day of aromasin for 5 days waited 2 days then had a blood test (in this case it was 4 days after my test shot).
Oestrogen 132 pmol/L (range <160). Note that this equates to 35 pg/ml (which I understand is higher than optimal). and i can see the water retention
Total Test 31.2 nmol/L (range 9.9 - 27.8) - still too high I suspect, although I do note that this was day 4 of a 7 day IM cycle so it would have declined prior to my next shot
SHBG = 23
Free Test = 977 pmol/L (range 170-670)
- Based on the above total and free test levels, It looks like i can lower my test dose even further. I was thinking moving to 100mg every 7 days. And from what i have read I should move this to 50mg every 3.5 days and go SUBQ (instead of IM) as this lowers aromatisation. Is this correct? does sub-q create less E2. i have no issue with IM shots, happy to stick with IM unless Subq is better to lower E2???
- Given this revised protocol, should I move my HCG injections to the day before each shot or the day of each shot? from what i read on here it doesn’t really matter? also As HCG increases E2 and my nuts feel big enough onn 250iu twice a week, can I lower this to 150iu twice a week instead?
- I aromatise like a bitch and I shocked that the 25mg day of aromasin still had my E2 so high! i hear aromasin has a short half life so needs to be dosed daily. I would prefer to use aromasin long term due to me needing so much Anastrozole and what it does to my lipid profile (and potential clotting issues). I was thinking using 12.5mg a day of Aromasin? anyone else who has high e2 use that level. Will try this 4 weeks then retest bloods
I do note that with higher E2 my libido is much better than lower e2. so i would rather be on the higher side (but lower than i am now!)