Help High E2 After PCT - Female

I had someone on KAL who was menopausal, stopped cycling. She resumed her periods. That may be atypical. But she ran out of KAL because the shop that carried is discontinued it and she tried another progesterone cream product that did not work and her periods and symptoms got messed up. Then with KAL, things were good again. The bio-availability is the issue.

T3,free range 1.8-4.6 result 2.5 pg/ml
T4,total range 5.1-14.1 result 7.0 Ug/dl
T4,free range 0.9-1.7 result 1.14 ng/dl
TSH range 0.27-4.2 result 2.860 uIU/ml

Thyroid ranges are useless.
TSH should be closer to 1.0, TSH=2.86 is a real problem.
T3, T4, fT3, ft4 should be mid-range or a bit higher.

fT3 is what supports one’s metabolic rate and fT3 is well below 3.2 midrange. Things could be worse than that if rT3 is elevated.

You both need to be using iodized salt to get iodine.
Did she take prenatal vitamins and during nursing?
Low iodine can cause this condition.
Prenatal vitamins do have higher iodine levels, for her and the baby. Iodine is stored in breast tissue to support the baby during nursing.

Please read this sticky and evaluate her overall thyroid function by checking oral body temperatures as suggested: Thyroid Basics Explained

White blood cell range 180-425 result 4.9 K/ul
Is this low=4.9 or high=4900?

Red blood cell range 3.8-5.5 result 3.82 m/ul
Hemoglobin range 11.5-15.2 result 11.3 g/dl
Hematocrit range 34.0-47.0 result 34.5 %
Total protein range 6.4-8.3 result 6.7 g/dl

The above suggests possible iron deficiency. Does she eat red meat? Takes an iron supplement or vitamins that list iron? Alternatively, a low level GI bleed from a food/digestive issue can do this. An occult blood test can rule that in/out.

She probably has a diet with lots of proteins and that makes lowish total proteins a point of interest.

AST/ALT do not suggest a liver issue that would reduce E2 clearance. But do keep in mind that it is the liver that removes estrogens from the blood stream.

It would have been interesting to see if LH/FSH were high, seeing that GH secretion appears hyperactive.
We would also want to see if prolactin is elevated.

Any changes to vision or reduced width of peripheral vision which should be around 180 degrees? Not concerned with refractive issues and needing corrective lenses.

I have seen some young guys messed up with prohormones that alter gene expression. So things like that are possible.

If E2 is elevated and LH/FSH are low, then E2 is inhibiting her HPOA and impaired E2 clearance is suspected. In that case, lower T is also a consequence and that can contribute to lower HTC and total proteins.

Edit: We know that low thyroid function causes some skin changes that can interfere with transdermal hormone delivery. We see that in males. This may be a factor. To overcome that, oral progesterone can be used [prometrium]. This also overcome possible problems from training/sweating and showering. If LH/FSH is elevated and responsible for high E2, that can be reduced by the inhibition of the HPAO by progesterone.