Heart Structural Changes from High Testosterone Levels

Why? If you have no energy, no focus, no libido, no ability to handle stress etc… that’s a pretty shit life. Regardless of what your number is. We don’t have to Chris Beniot murder our families, but being able to function and perform would be nice. That’s not hyper masculine or gender role confirming. I just want to be as sharp as I once was.

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What’s so difficult in understanding that there is a too little and a too much?

Totally agree, quality of life is of upmost importance. I just dont believe that if a guy walks into the dr. with borderline T numbers…complaining of the symptoms you mention that the first line treatment should be TRT. I would say the exact same thing for insulin and a borderline diabetic. Change your lifestyle and look at some of the core problems before moving to lifelong hormone or insulin therapy. I think its great that hormone therapy is more readily availabe to a wider range of men and that quality of life for men is an important discussion. But its important to note that there are alot of men who’s symptoms are not resolved from TRT and in some cases makes worse libido, focus, energy etc… Its a delicate situation with a lot of factors involved. And its not clear that the change in average testosterone numbers over time doesnt have some evolutionary basis. Maybe on average, its better for lower T numbers across the population. It doesnt preclude you or I from pursuing a certain quality of life. But the ultimate discussion becomes very specific to personal opinion and preference rather than medical necessity.

It is the job of the good doctor to really judge if someone needs TRT or not its not about philosophical shit but whether can improve quality of life

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Sometimes I feel like I was born in the wrong Era. When I was in 6th-7th grade my best friends dad was the caretaker of an exotic wildlife refuge full of huge animals from all over the world but many from Africa. They roamed wild like Jurassic Park in the middle of the woods/hills of Sidon, MS. It was called Thunderbird Ranch. He would drop me and my buddy (his son) off on Friday and pick us up on Sunday. We survived on what we killed and the shelters we built and the only tools we had were a lighter. In the beginning it was scary and felt like a world we weren’t made for but by the end it felt like the only world I wanted to be in. It came to an end when he died of cancer but those two years would forever change my life and the way I approach it. We’ve created a world that we aren’t suited for. Everyone should have to live with nature for a time to be able to appreciate life and understand why we are the way we are. I don’t know why I’m even posting this or what it has to do with what you’re saying but it’s what came to mind.

If anyone’s looking for a great read they should check out the book “Sapiens”.


To clarify, those would be intraday peak on a TT profile vs time that posseses a MUCH lower weekly AUC than a 3.5 or 7 day trough at the same value with use of exogenous testosterone ester. I know you know this but i want someone reading this to learn it and understand it.

Hence a man on the testosterone protocol could have 2-3x higher mean TT level (Cavg = 1500-2000 ng/dl) throughout the week than the top 1 percentile eugondal man (Cavg = 500-700 ng/dl).


Age and getting older reveals a different person with changing tolerance in some individuals.

You are replying to posts I made in 2019

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Yep. Still a very timely topic and I had something to add/clarify so that people reading these threads can appreciate some of these details. I am hopeful some new folks use the search function which will bring up potentially dated yet pertinent threads.

The discussion clearly sets up the concept that too low or too high has (-) consequences. Then we are left with invidual tolerance that then gives a distribution of responses to chronic exposure.


Here we show that supra-physiological concentrations of testosterone inhibit the urinary excretion of NO in healthy volunteers 48 hours after the administration of testosterone. Since urinary NO is a biomarker for endothelial function and mainly originates from the endothelium, our results indicate that even a single dose of testosterone may induce a decrease in NO formation in endothelial cells. One determinant of NO bioavailability is the expression and activity of eNOS, the main enzyme involved in the metabolism of NO in endothelial cells. Here we show that testosterone down-regulates the gene expression of eNOS after 48 hours. In a previous study it was shown that low doses of testosterone induce the protein expression and activity of eNOS in HUVECs and in rat aorta. These effects were lost when higher doses of testosterone were used, and in agreement with our findings, an inhibition in eNOS expression and activity could be discerned. [ 16 ]

Timely and relevant articles.



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You mention Yeti, but you post articles with zero clinical experience. You are a data analyst or whatever you are…

Yeti take a holistic approach and thats why his clients are happy and you do not see them all over forum boards complaining about TRT not working.

Hes a doctor who has dedicated his life to helping men and women. If it were not for him, many would not receive the help they need. Help that guys like you would refuse to give because you think you know it all . Here take 100mg , you are within range, enjoy your life. It must be something else.

You have zero creditiblity in my eyes and i dont see why you keep mentoining yeti. you are not at his level. not even close. if anything, you should pick his brain and learn from the man and realize how f ignorant you are.

im not wasting my time responding to your endless posts of graphs and stuidies. TRT is very simple. theres a reason our bodies need it. but you want to over complicated the shit out of everything.

Tareload alway spams threads with studies and graphs that seem relevant from afar, but up close, if you read them, are out of context. Nobody has the time to read them and he’ll just spam new ones anyway, so people don’t bother and the discussion dies out leaving only his posts ment to scare inexperienced readers.

I just randomly clicked one of his studies, the one on transgender males, and in the conclusion alone it literally says:
“ Testosterone is an acute vasodilator and in men may protect against endothelial dysfunction[27] Androgen receptors are expressed in cells throughout the cardiovascular system, including endothelial cells[28] and vascular smooth muscle cells (VSMCs) although the impact of testosterone administration on the cardiovascular system in men is varied[2]. In contrast, androgens may induce detrimental outcomes on the cardiovascular system in women[2] In general, the engagement of androgen and the androgen receptor results in impaired, agonist-triggered endothelial NO release in women, a likely cause of the sex differences in testosterone effects on endothelial function.”

See, he doesn’t really read them. He doesn’t care about the specific context of transgender men on testosterone therapy and just applies it to cisgender men. He only skims through studies looking for scary buzzwords or graphs to spam. Of course if people only read the title that was posted they will actually think the study shows testosterone is harmful. “I never said that”, yeah, but you definitely ment to imply it.

Do you really think pushing testosterone concentrations up past physiologic concentrations is healthy?

Will it kill you instantaneously?


Will it take 5-10-15-20 years off? Who knows?

Depends on a myriad of factors… genetics being by far the largest predetermining factor.

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Take it easy man. I wish you the best.

One last one in honor of you.




Will be nice when a genetic screening tool is available to test genes for AAS suitability. Then those that are eligible can blast away :slight_smile: .

Or just clone @hankthetank89 and everyone can use him for gene therapy.

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Stop talking about him in Third person, you are the same Guy. Nichols is a shit doctor with Napoleon complex, extremely emotionally reactive and tryhard, he is Short as hell and just awkward. His (your) debating skills are the worst ive ever seen and its a disgrace that People with such low iq can become a doc these days.

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Oh wow. Looks like the person with the complex is you. Amazing how you can just casually be such a D towards someone who you disagree with.

I bet you live your life without judgement and listen to those that disagree with you

Ill do whatever you want. Ill trigger you and make you feel so much. With very few words im sure.

Why are you guys always so angry and hateful. It amazes me.

:rofl: third person… just listen to you. you are a disaster of a human being.

Fun fact

Napoleon is said to have been around 5’6

Perfectly average height for someone of his time.

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Well… this is the pot calling the kettle black isn’t it?


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This can’t be serious :thinking:

Like come on this is an obvious troll or the dude seriously has some bi polar or amnesia problems…. Or something, this isn’t normal.

Definitely getting a bipolar vibe in these threads. Nothing to mess around with or denigrate. I hope they find peace and help.

There are these large bursts of activity and then nothing (almost like a solar storm) from our buddy with the many handles.

Health first. Take care everyone.

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