HCG on TRT, Effectiveness and Potential Side Effects?

hCG at 250iu subq EOD does not have negative effects in almost all cases. The effects of not using are shrinking testes and a scrotum that is pulled up tight. Some then also have a dull 24x7 ache in their testes. Many who have been on TRT without hCG, report a good improvement on mood when hCG is started. So we are aware of some effects independent of T level effects.

hCG simply provides LH receptor stimulation the same as LH.

Gyno is from estrogens, not hCG. Most men need an aromatase inhibitor [AI] to keep estradiol [E2] in a favorable level near E2=22pg/ml - 80 pmol/L.

When you post lab work, always include ranges.
We often pick up issues that doctors miss, try to post all of your labs.

Ask for:

  • self inject 50mg T cypionate twice a week, subq with #29 1/2" 0.5ml insulin syringes [Not 1.0ml !]
  • 0.5mg anastrozole at time of injections
  • 250iu hCG subq EOD

Many here have thyroid issues, often from not using iodized salt. See related below.


Please read the stickies found here: About the T Replacement Category - #2 by KSman

  • advice for new guys - need more info about you
  • things that damage your hormones
  • protocol for injections
  • finding a TRT doc

Evaluate your overall thyroid function by checking oral body temperatures as per the thyroid basics sticky. Thyroid hormone fT3 is what gets the job done and it regulates mitochondrial activity, the source of ATP which is the universal currency of cellular energy. This is part of the body’s temperature control loop. This can get messed up if you are iodine deficient. In many countries, you need to be using iodized salt. Other countries add iodine to dairy or bread.

KSman is simply a regular member on this site. Nothing more other than highly active.

I can be a bit abrupt in my replies and recommendations. I have a lot of ground to cover as this forum has become much more active in the last two years. I can’t follow threads that go deep over time. You need to respond to all of my points and requests as soon as possible before you fall off of my radar. The worse problems are guys who ignore issues re thyroid, body temperatures, history of iodized salt. Please do not piss people off saying that lab results are normal, we need lab number and ranges.

The value that you get out of this process and forum depends on your effort and performance. The bulk of your learning is reading/studying the suggested stickies.