Found a copy of an article on another forum this was apparently posted by the endocrinology society.
Does anyone have real life experience with such a protocol as below? I may have the option of testing HCG monotherapy so I am trying to decide which is the better way to go.
Not sure if I understand it correctly but are they trying to say that if you inject multiple times per week, those subsequent injections are not effective after the initial dose? So you are better off waiting 7 days before injecting again?
An in vivo injection or an episode of LH secretion induced by GnRH, results in stimulation of the side-chain cleavage enzyme with the subsequent release of testosterone within 30-60 minutes of LH stimulation. The acute response to an injection of LH is dramatic in some species such as the rat and the ram but is much more attenuated in the human. This testosterone response lasts approximately 24-48 hours. If human chorionic gonadotrophin is used as an LH substitute, the kinetics of the initial stimulation are similar to LH but a second peak of testosterone secretion is evidence with hCG and occurs 48-72 hours after the initial injection. This biphasic pattern has been attributed to the observation that between 24 and 48 hours after an LH or hCG injection, the Leydig cells are refractory to further stimulation by either hormone. The second phase of testosterone secretion after hCG but not LH is associated with the longer half-life of hCG in comparison to LH. The hCG levels persist in the circulation and, following recovery from the refractoriness, testosterone levels increase. This observation has significant clinical importance since, in many men, a single weekly injection of hCG will suffice to maintain optimum testosterone responses rather than the frequent practice of giving injections of hCG two to three times per week.
The stimulation of leydig cells with large amounts of hCG rapidly reduces their number of receptors, this phenemenom is termed down-regulation.
Although these changes decrease testosterone levels to just above diurnal maxima 24-48hrs after initial injection repeated stimulation does not yield the same results.
A single injection of hCG is followed by a long steroidogenic response characterized by two phases of testosterone secretion.
Studies show that this second phase which can last as long as 8 days can increase testosterone in plasma by 2.2 x above maximal diurnal secretion even though hCG is no longer present in plasma.
The results indicate that hCG injections can be given every 6-7 days due to the prolonged steroidogenic response.