I would have to know what pathway was affected.
Try not to look into some much information because it will drive you crazy. IF you feel good on this protocol run with it. Nothing going to be perfect so as long as you are feeling good its the end results. When people trying to micromanage HRT it will make one more stressed out. Its good to educate your self, but do not look into things too deep. Since I have been telling people this, they have notice a better response from treatment.