You can front load adex to overcome the typical time of 6-7 days to reach static levels.
As a rule of thumb, normal anastrozole responders will need 1.0mg adex per week [in divided doses] per 100mg of test ester per week.
First time dosing should not use a front load as the consequences can be unpleasant for those who are over-responders. Once you know that your response is normal, you can front load when increasing dose or resuming use.
Liquid products do allow fine dose change increments.
The change in T–>E2 aromatization rates is almost instantaneous. Adex absorbs very well. The serum levels of E2 are a balance of production rates and E2 clearance rates in the liver. Thus E2 levels take time to change. Couple that with a lag time building serum anastrozole levels with a constant dose and things take longer. The the cells respond to the lower E2 rates. Some of that is reduced E2 blockage of T receptors and some is altered E2 mediated gene expression. Changing gene expression leads to changes in the cells and that takes time. In TRT settings, lowering E2 levels to near E2=22pg/ml creates significant changes in 10-14 days.
One should be seeking optimal E2 levels to maximize the effects of one’s T dose. E2=22pg/ml seems to be optimal from a libido point of view and that would seem to be a good proxy for things working right.
In PCT, you need to taper off of adex, but that should follow T levels that lag reductions in T dose. You should end up taking 0.5mg during PCT and continue that for a month after PCT to avoid estrogen rebound, then taper out.
Never stop SERMs suddenly, taper out and land on low dose adex.[/quote]
So unless I have misinterpreted your post, the recommendation for somebody considering a cycle of 500mg of test per week would be around .70mg of adex ED?
Now I know these things are highly individual - and I commend your effort in trying to give users a useful rule of thumb for adex use, but this seems to go against the culturally accepted dose of adex for AAS users (seems high).
Purely playing devil’s advocate for the purposes of discussion here, but this ‘bro knowledge’ (if you want to call it that) may have some scientific backing:
A number of authors contend that the efficacy of Test is due to aromatization.
‘During puberty there is a disruption in your body’s ability to accurately regulate GH levels leading to increased GH, IGF-1, and insulin levels. This combined with elevated testosterone production characterizes puberty. Research has shown that this disruption is caused by the aromatization of testosterone as well as some direct actions of androgens 4,5,6,7,8.’
The studies for those interested:
- Veldhuis JD., Metzger DL., Martha, Jr. PM., et al: Estrogen and testosterone, but not nonaromatizable androgen, direct network integration of the hypothalmo-somatotrope (growth hormone)-insulin-like growth factor axis in human: Evidence from pubertal pathophysiology and sex-steroid hormone replacement. J Clin. Endocrinol Metab. 82(10):3414-3420, 1997
- Ulloa-Aguirre A., Blizzard RM., Garcia-Rubi E., et al: Testosterone and oxandrolone, a nonaromatizable androgen, specifically amplify the mass and rate of growth hormone (GH) secreted per burst without altering GH secretory burst duration or frequency or the GH half-life. J Clin. Endocrinol Metab. 71(4):846-854, 1990
- Illig R., Prader A. Effect of testosterone on growth hormone secretion in patients with anorchia and delayed puberty. J Clin Endocrinol Metab 30:615-618, 1970
- Mauras NM., Blizzard RM., Link K., et al: Augmentation of growth hormone secretion during puberty: Evidence for a pulse amplitude-modulated phenomenon. J Clin Endocrinol Metab. 64:596-601, 1987
- Kerrigan JR., Rogol AD., The impact of gonadal steroid hormone action on growth hormone secretion during childhood and adolescence. Endocr Rev. 13:281-298, 1992
So If I interpret this correctly, AAS users whose primary goal is hypotrophy should be careful not to take to much adex, as they may well cut into your muscle gains by virtue of a less robust GH burst activity and lower subsequent IGF-1 levels.
The question I suppose is always how much is too much for any individual?
I’ll be running a ‘cut’ cycle in run up to our hot Australian summer with 500mg of test per week, so I’ll probably take your advice and run .7mg adex ed with the goal of maximising fat loss and see how i go.