I've seen it written here that hCG does not directly cause gyno flare ups, but my experience has proven otherwise. In addition, I've read elsewhere that breast tissue can be directly stimulated by hCG. And it makes sense because that is one of the "hormones" that is released in higher volume when a woman's breasts enlarge during pregnancy. Breast tenderness, feeling a little emotional, nausea and fatigue – they’re all due to hCG surging around the pregnant body.
And guys' chests can be affected too:
Maybe some guys also have breast tissue that is directly sensitive to hCG? I read somewhere that hCG can cause increased paracrine oestrogen formation. I.e. it makes mamary tissue localy produce estrogen. And aromatase inhibitors can't do much about that...
Been on TRT for 3 months...I have my numbers in check on 120mg test cyp per week (given in 2 doses of 60mg) and .50mg Arimidex (given in 2 doses of .25mg). Just 2 weeks ago I added hCG at 500iu per week (given in 2 250iu) and I immediately noticed increased nipple sensitivity and nodular glands appearing behind both nipples.
Labs from 1 week ago:
Total Test: 1157 (348 - 1197)
Free Test: 20.6 (8.7 - 25.1)
E2 (Sensitive): 24.6 (8.0 - 35.0)
hCG converts to test which can aromatize to estrogen. Some here and other forums have said that an AI is less effective at stopping this aromatization, with it occurring in the testes. However, I'm not sure of the science behind such claims, as the excess estrogen would eventually make it's way into the blood and the AI would theoretically be effective at treating this, no? In addition, my e2 has been kept in check by the AI, as you can see by the number above, labs taken 1 week after starting the hCG and noticing the gyno. So I think it's more likely that some men have overly sensitive beast tissue. Why? Is it genetic or some ratio of hormones... I still don't know.
Changes made: I lowered hCG dose from 250iu E3.5D to 125iu. In addition, I picked up some raloxifene, which has been shown to be an even more effective SERM than nolvadex for treating gyno, and have been taking 60mg/day for the last week and there has been an almost immediate decrease in nipple sensitivity and nodule size.
One thing I have noticed is that raloxifene negatively impacts my libido (which has been substantially increased since starting TRT.)
So...I'm at a loss for what to do. Obviously, raloxifene is not a long term solution. I don't want to take more AI, and I don't want to stop taking hCG since I'd like to preserve my fertility (and nut size).