T Nation

Grapefruit Juice

I thought I’d start a nice new thread for this, instead of cluttering up dirty99’s thread (sorry!)

Anyway, continuing from what was originally discussed here(bottom of page 1):

http://www.T-Nation.com/tmagnum/readTopic.do?id=2364945

---------------------------------

GRAPEFRUIT JUICE DRUG INTERACTIONS
This food-drug interaction was actually discovered by accident. A study that was intending to test the interaction of alcohol and a blood pressure medication, used a mixture of alcohol with grapefruit juice to disguise the taste of alcohol for the study. Ironically, alcohol had no effect on the tested medication, but the grapefruit juice seemed to enhance the absorption of the drug.

The researchers then confirmed the finding by comparing drug levels when taken with either grapefruit juice or water and found five-fold higher blood levels of the drug when it was taken with juice. Orange juice did not show this effect.

Grapefruit juice inhibits a special enzyme (CYP3A4) in the intestines that is responsible for the natural breakdown and absorption of many medications. When the action of this enzyme is blocked, the blood levels of these medications increase, which can lead potentially toxic side effects from the medications.

Research has suggested that flavonoids and/or furanocoumarin present in Grapefruit are the substances that act to block the enzyme in the intestines that normally metabolizes many drugs.

Some medications that interact with grapefruit juice:

Statins (Cholesterol Lowering Drugs)
Antihistamines: Terfenadine
Calcium Channel Blockers (Blood Pressure Drugs):
Anti-convulsant: Tegretol (Carbamazepine)
Anxiolytics: Valium (Diazepam)
Anti-depressant: Sertraline Clomipramine
Cortico-steroids: Methylprednisolone
Oestrogens: Ethinyl estradiol
Anabolic Steroids: Dianabol
Impotence Drug: Viagra

Although some drugs are given with others to enhance their effects, grapefruit juice should not be used for this purpose because its impact can be unpredictable and potentially dangerous.

The above list is by no means exhaustive. Please consult with your doctor or pharmacist regarding possible interactions between grapefruit juice and medications you may currently be taking if you consume grapefruit/ juice regularly.

[i]Grapefruit juice-drug interactions.
Bailey DG, Malcolm J, Arnold O, Spence JD.
Department of Medicine, London Health Sciences Centre, Ontario, Canada.Br J Clin Pharmacol. 1998 Aug;46(2):101-10.

http://secure.pharmacytimes.com/lessons/200303-02.asp[/i]

--------------------------------------

i don’t use oral steroids much but when i do I try to take them with grapefruit juice just to get a little more bang for my buck.

i think TC wrote about this about a year back in a pretty good article. he was talking about taking supplements with grapefruit juice and I thought it should work even better with d-bol

Is it JUST D-Bol that has that interaction (WRT AAS) or does the same occur with any oral steroid?

it should happen with any type but I don’t know that for sure, it’s just a guess based on what I remember of TC’s article. I think DBol is just the one they tested because it is common.

[quote]FuriousGeorge wrote:
it should happen with any type but I don’t know that for sure, it’s just a guess based on what I remember of TC’s article. I think DBol is just the one they tested because it is common.[/quote]

HEy good spot FG.

I’m currently in on another of my 2 weekers of drol/win at the mo’. Looks like I’m going to the grocery store for some grapefruit juice tonight to commence with the experiment.

I have done more than enough of this cycle to know if there’s a difference to notice. Sound good anyone?

Yipeee.

ToneBone

[quote]Dave_ wrote:

Some medications that interact with grapefruit juice:

Anabolic Steroids: Dianabol

[/quote]

How much grapefruit juice should be taken? Would it be enough to just take your meds with grapefruit juice throughout the day? I take in pills almost every meal, so that could add up to 16oz or so of the stuff?

[quote]BestDaddyEver wrote:
How much grapefruit juice should be taken? Would it be enough to just take your meds with grapefruit juice throughout the day? I take in pills almost every meal, so that could add up to 16oz or so of the stuff?[/quote]

I’ve heard 250mL.

[quote]BestDaddyEver wrote:
Dave_ wrote:

Some medications that interact with grapefruit juice:

Anabolic Steroids: Dianabol

How much grapefruit juice should be taken? Would it be enough to just take your meds with grapefruit juice throughout the day? I take in pills almost every meal, so that could add up to 16oz or so of the stuff?

[/quote]

An article I found said that a single “glass” every morning is enough to have a significant effect. I’ll try to find it this evening for you guys.

The active life of the compound(s) is around 24hrs, I believe this figure is based on a glass full.

BE careful however, eph and caffiene are both strongly effected by grapefruit juice. I suggest NO stims or even painkillers whilst trying this approach. In fact, only even think about it if you’re on NO meds at all (except AAS, obviously).

Dave

Very interesting read. Good find Dave.

This post was flagged by the community and is temporarily hidden.

…would suggest fresh grapefruit juice if possible - niagrin, the active ingredient in grapefruit is found mostly in the peel and flowers.

niagirin inhibits the breakdown of the xanthines in caffeine in the liver. i learned this in dan duchaine’s book.

i faithfully chase my 1/2 can Spike with a glass of grapefruit juice every AM before working out - and i stay pretty energized for most of the day.

How soon before 98lb steroid guru’s in their bedroom advise other newbs to inject the grapefruit juice…LOL

This post was flagged by the community and is temporarily hidden.

Just thought I’d post this up again from the other thread in case anyone missed it…

http://news.bbc.co.uk/2/hi/health/6900482.stm

Basically, the study suggests grapefruit raises E levels in post-menopausal women, contributing to the development and metastasis of E dependant tumours.

Not exactly an RCT, so the study is in no way conclusive. This shouldn’t be a factor on cycle anyway though if using an AI I imagine.

Alt: Someone sensible like yourself can undoubtably judge how to use the grapefruit tactic, I just don’t want some kid taking an ECA stack with a gallon of GFJ and getting an MI!

:wink:

Oh yeah, I forgot to ask,

Alt: Do you use grapefruit on cycle to enhance the effect of your oral steroids?

I would like to hear Bushy’s opinion on the subject too, but I heard that he doesn’t take class IIs because of the back pumps…

Damn just typed a post and it disappeared…

Alt: Do you take grapefruit juice on cycle to enhance the effect of your oral steroids?

I would also like Bushy’s opinion on this but I seem to recall that he doesn’t take class IIs because of the backpumps…

[quote]BestDaddyEver wrote:
Dave_ wrote:

Some medications that interact with grapefruit juice:

Anabolic Steroids: Dianabol

How much grapefruit juice should be taken? Would it be enough to just take your meds with grapefruit juice throughout the day? I take in pills almost every meal, so that could add up to 16oz or so of the stuff?

[/quote]

The BBC article said that women who ate at least 1/4 of a grapefruit were the ones who were at 30% higher risk for breast cancer. So I would presume that eating 1/4 grapefruit should do the trick.

This post was flagged by the community and is temporarily hidden.

This post was flagged by the community and is temporarily hidden.

[quote]AlteredState wrote:
xXDevilDogXx wrote:
BestDaddyEver wrote:
Dave_ wrote:

Some medications that interact with grapefruit juice:

Anabolic Steroids: Dianabol

How much grapefruit juice should be taken? Would it be enough to just take your meds with grapefruit juice throughout the day? I take in pills almost every meal, so that could add up to 16oz or so of the stuff?

The BBC article said that women who ate at least 1/4 of a grapefruit were the ones who were at 30% higher risk for breast cancer. So I would presume that eating 1/4 grapefruit should do the trick.

Interesting because I remeber years ago something called the ‘grapefruit diet’ in which if you ate half a g’fruit before each meal, you would not absorb some of the fat/calories from that meal, so you would effectively lose weight.

Awesome. Lose weight but get breast cancer.[/quote]

I remember that craze too. I guess there is always a trade off :wink: