After discussing Cytochrome P450 (superfamily of enzymes) in my pharmacology class ive been looking into the affects of grapefruit on it. Grapefruits essentially decrease cytochrome P450 increasing the bioavailability of certain drugs. P450 also plays a role in aromatase, so if you inhibit P450, from what I can tell you would inhibit aromatase? Can anyone confirm if this is correct? a subset of P450 also plays a role in steroidogenesis, so if grapefruit inhibits P450, are you also inhibiting steroidogenesis?
Basically is the aromatase inhibitory effects of grapefruit worth reducing steroidogenesis? probably not but I'd like to hear other people's opinion on this who have a better understanding of it than I do.