[quote]Headhunter wrote:
KSman wrote:
So the HPTA still gets shutdown, testes atrophy and may go into a state of organ failure. Pregnenolone production drops, which undermines DHEA levels and thus cortisol levels might drop. Any state of adrenal fatigue would get worse.
So one still needs to inject hCG. So one is still injecting. I do not think that pellets will work as well as EOD T injections. And the levels from the pellets drop over time until new pellets are inserted.
One can inject T EOD at the same time as EOD hCG injections.
Self injecting remains the least cost option.
When one does lab work with pellets… when does one do the labs after the pellets are inserted? What does that number mean?
If T levels fall over time, then one’s adex dose will never be right in terms of T relative competitive action.
A constant dose of around 3 mg of test per day is constantly released into the body – no ups and downs, and it more mimics how we’d normal get T.
Why would the injections EOD avoid all the trouble you mention, but the pellets won’t? The pellets seem to have the advantages of the gels w/o their drawbacks.
The only drawback top guys in the field say are that, if your level is too high, the pellets would have to be surgically removed. F that, I want high! 
[/quote]
Pellets wear out and they do not provide the same mg/day as they age.
Note references to peak and trough levels.
“”"
While your optimal, long term dose is being determined during the first 12 to 18 months of pellet therapy, blood levels will be taken at four weeks (peak levels) and at 10-14 weeks (trough levels) after each insertion.
“”"
Look at the chart of T vs time:
http://jcem.endojournals.org/cgi/reprint/82/8/2510.pdf?ck=nck
Note how E2 follows the same track. The intent of the study was something else. Note that some were injected every 3 weeks… horror! Others were pelletized. The T levels for pellets were way higher at peak. I could not see what the dose was for the T injections. The levels were checked after 3 weeks and then re-injected. So we should expect to see rather useless levels from that. But this is all a distraction from the charts data for pellets. Pellets and infrequent injections were simple a cost effective method of getting some guys on T to study the effects on leptin.
Note the SHBG repression by T, even with increasing E for both methods. In the charts, note where INJECTED T treatment ended on day 189.