The omega 6/GLA pathway does lead to arachadonic acid. However it also leads to the production of anti-inflammatory eicosanoids (book is at home with which specific ones).
people also have to remember that its not just a simple, pro or anti inflammatory action that we are looking.
Some of the EPA series prostaglandins are pro-inflammatory, however the strenght is less than ALA derived cytokines.
Its more complex than good bad nothing inbetween sort of stuff.[/quote]
OK got Udo’s book in front of me.
I can certainly see how (assuming Udo’s diagram on page 20 still bears resemblance to reality):
GLA–>DGLA–> series one prostaglandins
DGLA–>AA–>series 2 PG (and other bad stuff).
But the question for someone who is not a scientist but who does recommend supps is, is the net effect anti-inflammatory e.g. I currently recommend EPA/DHA + gla as part of a post surgery regimen (once bleeding has stopped). Is there anything to say I should take GLA out of this mix? GLA also seems to work well for diabetic neuropathy.
It occurs to me that the enzyme (delta 6 desaturase) converts DGLA–>AA BUT has a higher affinity for ALA (flax) then DGLA. So if there is any question of GLA having a net inflammatory effect, one can take flax with the GLA and prevent (or decrease) the conversion of DGLA–>AA.
On a related topic, the reason Barry Sears (of Zone fame) dislikes (last I heard) flax is because flax competes for delta 6 desaturase and decreases conversion of LA—>GLA. While I suspect there may be some truth to what he says, this can be prevented by having anyone taking flax take GLA. Right?