Here's the article, it's kinda long but here it is:
-GHRP-6 and Hexarelin
By Anthony Roberts
Earlier this year, I was interviewed by a major online bodybuilding site (the
interview was titled ???Chemically Insane???), and in that interview, I
predicted that various peptides would become the newest trend in performance
enhancing drugs. For the most part, I was correct, and now they???re very
popular and widely available, although still relatively new.
So, several months ago, I began my experimentation with various peptides, mostly
with the goal of figuring out the best way to use them. My last major article
examined my experiences with the two most popular peptides ( IGF and MGF)
currently on the market. This time around, I???m going to tell you about my
experience with Hexarelin and GHRP-6, two lesser known peptides. With Lr3IGF-1,
the use and goals of use is pretty straightforward???you pretty much use it to
gain muscle and lose fat; on rare occasions, people use it to rehab an injury (I
actually provided a full rehab protocol using IGF-1 in my first e-book). With
MGF, it???s even simpler???you use it to increase muscle size, period.
Using the other peptides is a bit more complicated, and there are a couple of
other reasons you might want to consider using them???but I???m getting a bit
ahead of myself. The first thing I do when I???m researching a new anabolic is
to jump on the internet and do some research in all of the available medical
databases, and exhaust every search engine imaginable with keywords related to
the new compound. The next thing I do is typically to get a couple of vials and
try it for myself. I???m in a very unique position with regards to trying new
compounds; in the case of several compounds (Esterless Boldenone, Masteron
Enanthate, Stealth Injectables, etc???) I was actually able to try the products
before they were released to the general public. In the case of Hexarelin and
GHRP-6, I have had the opportunity to experiment with them for the past few
When I first received my vials of GHRP-6 and Hexarelin, I did what most people
probably do???I reconstituted them, shot first, and asked questions later. I
thought it would be a great idea to fire up 600mcs of GHRP-6 just before a heavy
max effort deadlift session. Bad idea. I have a 45 minute drive to my gym (I
happen to workout at a military academy, where I coach), and halfway there, I
started to get a bit hungry. No problem, right? We???ve all worked out a bit
hungry???well, that???s what I thought at first. Then when I hit about 400lbs
into my deadlifts, I started getting dizzy???I broke into a cold sweat, and I
had to sit down. I rushed to get some simple carbs into my body as quickly as
possible, thinking that I was going hypoglycemic. Ok???I wasn???t going
hypoglycemic, but it was pretty bad. That workout was shot. Still, I was
wondering if I could actually slip into some kind of severe hypoglycemia from a
shot of GHRP-6???it certainly felt like I could.
So, naturally, I was interested, and did some experimenting. I waited a day and
invited a friend over to my place???then I did another shot of 600mcg (split
bilaterally, 300mcg into each leg, as a subcutaneous shot). Then we sat around
and waited, with a bunch of simple carbs ready. I got hungry, I was
uncomfortable, and it wasn???t too much fun, but we sat there for a good couple
of hours, and I didn???t pass out (in case you???re wondering, the friend was
there to drive me to the hospital, in case I actually did pass out). Ok???so
that settles that. Originally, I thought that maybe GHRP-6 operated by inducing
some kind of mild hypoglycemia (hypoglycemia increases GH output). But that???s
not how it actually works???
Growth Hormone Releasing Peptide- 6 (GHRP-6) is a synthetic hexapeptide which
stimulates the release of Growth Hormone. It accomplishes this by two totally
separate mechanisms. On the one hand, it amplifies your body???s natural Growth
Hormone Releasing Hormone (GHRH) signal transduction pathway, and on the other
hand, acts as a functional antagonist of the hormone which causes inhibition of
GH secretion (somatostatin) (1-3).
GHRP-6 also has the benefit of being able to directly stimulate the anterior
pituitary gland, resulting in increased GH release. So although my initial
thoughts on the mechanism of action for this stuff was wrong, I was enthused
when my research revealed that GHRP-6 induced GH secretion occurs by several
mechanisms. Most importantly, those mechanisms are the induction of GHRH release
from the hypothalamus, stimulation of GH release from somatotrophs, joint
actions of GHRH and antagonism of somatostatin, and finally by pronounced
antagonism of somatostatin action on somatotrophs (1-4). However, it bears
clarification that GHRP-6 is not dependant on the GHRH pathway???it can boost
your growth hormone levels without necessarily needing to elevate GHRH. This is
important because if that pathway has been inhibited by long term GH use, GHRP-6
can still get your body producing and releasing GH.
Additionally, this peptide can also act on the central nervous system, which can
provide added benefits in neuroprotection as well as muscular strength increases
for the user. Much of the strength increases we see with Anabolic Steroids in
the Dihydrotestosterone family are suspected to be through a similar stimulation
of the Central Nervous System. In my experience with GHRP-6 use, strength levels
typically go up within the first week of starting out.
Increases in Growth Hormone levels in the body are typically accompanied by
strength increases, muscle hypertrophy (growth), and lipolysis (fat loss). Other
results experienced with increased GH levels are recuperative effects on joints
and injuries; connective tissue strengthening and bone mineral density
improvements are commonplace. Enhanced GH secretion also leads to the liver
secreting more IGF-1 (Insulin-Like Growth Factor 1), which is thought to be the
primary anabolic mechanism of action for Growth Hormone. In the case of GHRP-6,
I gained quite a bit of weight when I was running it at the 600mcg/day level. I
think that this was probably due to overfeeding that almost always accompanied
my shot contributed to this weight gain. I gained about 12lbs in 2 weeks. I
think that the same way people often throw EQ into bulking cycles to increase
appetite stimulation, I would suggest using GHRP-6 instead. It???s not anywhere
near as anabolic, but the appetite increase is far a!
bove anything I???ve ever experienced with any anabolics.
The women I know who have used GHRP-6 all had to discontinue its use because it
was making them gain weight too quickly. But then again, most of the women who I
know are national level (or professional) physique competitors, and at most need
an additional 5-10lbs of muscle at most. GHRP-6 just put too much weight on them
After experimenting with GHRP-6 for weight gain, I lowered the dose
substantially and used it to help rehab a knee injury that had been bothering me
for a couple of years. In this case, I lowered it to 100mcg/day, shot sub-q into
the knee (ouch!). At this dose you won???t find the extreme hunger that a high
dose of it usually causes, and a 5mg bottle of GHRP-6 is going to last for
months, and I???m confidant that it???s going to be enough to rehab virtually
any injury (in my case, I had done extensive damage to my knee over the years,
culminating in a traumatic injury playing on turf???which resulted in my
semi-retirement from competitive athletics). Anyway, I combined GHRP-6 with a
knee rehab protocol designed by Eric Cressey, M.A. C.S.C.S., and advice from one
of my research assistants, who has a degree in Sports Medicine. Taken this way,
I used GHRP-6, and rehabbed my knee to almost where it was prior to my beginning
my career in athletics. If you have an injury, find you!
rself a good rehab protocol, and try a low dose of GHRP-6. I bet you???ll be
Oh???and this brings me to another point. I???m sure most people subscribe to
the theory that peptides only last for a couple of weeks in their reconstituted
form. Well, after I had my GHRP-6 reconstituted for well over a month, I tried a
shot at my old 600mcg dose, and guess what happened? Yeah, I got a huge increase
in appetite within the hour. This tells me that we???re really underestimating
the amount of time that a reconstituted peptide can retain its potency. I???m
betting we have months, not weeks.
Since GHRP-6 acts directly on the feedback loop which signals the inhibition of
GH release, it has been used immediately following either GH or IGF-1 cycles, to
recover natural GH production by inhibiting somatostatin action. It has also
been used concurrently with those compounds to negate some of the effects of
those compounds on natural GH production. Most people who use IGF never actually
realize that as IGF is part of the hormonal cascade that GH initiates, it is
also part of the Negative feedback loop for it.
Typical doses of GHRP-6 range from 100mcg/day injected subcutaneously (for
connective tissue strengthening) to 500mcg/day (for an anabolic effect). After
experimentation with a wide variety of doses, and input from several people who
have also used the product, I think that 500mcg/day is the upper limit of
effective dosing for GHRP-6.
The most rapid side effect experienced with GHRP-6 is extreme hunger, which
typically occurs within an hour of injection. This could be due to a possible
effect on blood sugar lowering, or more likely (I suspect) due to its influence
on Ghrelin (5), stimulated by the peptide influenced release of GH. Ghrelin, by
the way, increases appetite and speeds gastric emptying. This means???even if
you weren???t hungry a second ago, and your Ghrelin levels go up too
much???you???ll be starving soon.
If I were looking to figure out the best way to use GHRP-6 in a bulking cycle, I
would simply take my favorite bulking cycle, and run GHRP-6 with it at a daily
dose of 600mcg/day, shot post-workout. The reason for the post-workout dosing is
to take advantage of the appetite stimulating properties, at the same time as
taking maximum advantage of the anabolic properties of the GH release that it
will cause. And I???d probably consider using some insulin as well, because
insulin is highly anabolic on its own, but also because the GH response to
GHRP-6 is elevated with concurrent use of insulin (6). Again, this is only how
I???d do it personally, and I???m sure people will experiment with things and
find the optimal way to get the results they want on an individual basis. GHRP-6
and this is no exaggeration, will put as much weight on you as nearly any
steroid. If you???re not careful, you???ll gain too much fat???my recommendation
is to use this stuff on your off season bulking !
Overall, I was pretty impressed with GHRP-6, in my experience with it. Its
ability to put weight on me was actually too potent, although the strength gains
were nice. Now, I???ll mostly use GHRP-6 for post cycle therapy from IGF use, or
when I need to get rid of an injury.
I???ve never used Growth Hormone (let???s face it???it???s expensive, and
Lr3IGF-1 + MGF is a much better buy), but when I used Hexarelin, I experienced
most of the results that GH users report, but in much less time. Out of the two
GH secretagogues that I tried (Hexarelin and GHRP-6), Hexarelin is definitely my
favorite. In my own personal case, I???m 28 years old right now, and not looking
to add any more mass. I can comfortably maintain my bodyweight with my
doctor-prescribed anabolics (I???m on permanent Hormone Replacement Therapy),
and now I mostly focus on athletic-oriented goals. So strength gains without
much weight, and maybe a bit of bodyfat loss, are my primary concerns. If I were
in my early 20???s and still looking to gain weight, I???d probably be in love
with GHRP-6, but for this stage of the game, I prefer the effects I???ve found
Hexarelin is a GH secretagogue, specifically a hexapeptide which stimulates the
release of growth hormone ( GH) in both GH deficient as well as normal humans.
When given by injection, plasma growth hormone concentrations increased (with a
dose-dependent response curve). Growth Hormone levels peak at the half-hour mark
after injection, then decreasing to baseline values within roughly four hours
(half-life is about 55 minutes).
Of course, as we know from other peptides like GHRP-6, this type of surge in
Growth Hormone levels has been positively correlated with increases in strength,
muscle hypertrophy, and fat loss. Therefore, the many advantages of having GH
secreted in larger amounts via administration of Hexarelin are comparable to the
effects of injectable growth hormone administration. In my own case, I found
that Hexarelin increased my strength and even aided with fat-loss a bit, but
didn???t put much weight on me at all. This makes it very different from GHRP-6,
which piles tons of weight on me.
Although my knee injury was, for the most part, totally healed from my use o
GHRP-6, I suspect that Hexarelin would have produced very similar results or
that purpose. That???s because, as we already know, increasing GH levels elicits
a favorable increase in bone mineral density. When I used Hexarelin, however, I
was mostly interested in the increase in GH which would provide me with both
increased mitosis and meiosis (each of which leads to hypertrophy, i.e.
increased muscle size), triglyceride hydrolysis which helps aid in fat loss. And
since there are GH receptors (though no IGF-1 receptors) in adipose tissue, I
decided to use my Hexarelin subcutaneously in my abdomen. Even though the GH
response is systemic (whole-body), it couldn???t hurt to concentrate the shots
where fat is more highly concentrated (which in males is the abdomen). I used
200mcg/day of Hexarelin, shot sub-q (in my case, being under 100kgs, this is
just slightly over the maximum response dose...as I lat!
er found out).
Hexarelin enhanced GH secretion also leads to the liver secreting more IGF-1
(Insulin-Like Growth Factor 1). IGF-1 is thought to be the primary causative
factor in the anabolic effects of Growth Hormone. It needs to be noted at this
point that data on this is actually conflicting, and I???ve seen studies where
(somehow?) Hexarelin elicits a release in GH without a commensurate increase in
IGF-1 levels. In my own experience with Hexarelin, I found it to be reasonably
anabolic on its own, but lets be realistic here; it???s important to realize
that Hexarelin is not going to produce results similar to high dose GH cycles,
in the normal person. This is because Hexarelin only stimulates the increase of
GH, and has been found to be effective up to 2mg/kg, but after that dose does
not really produce more results in terms of GH secretion (7). Thus, a dose of
2mgs/kg is the upper limit for Hexarelin use, while GH users in the professional
ranks of athletics and bodybuilding have gone!
as high as 10iu/day. Hexarelin, at 2mg/kg of bodyweight has been compared by
most users to the type of results seen with 1-2iu/day of GH. At the price,
though, Hexarelin is a much better alternative. If you need the type of results
that 3iu+/day of GH are going to give you, then that???s an impossibility with
Hexarelin use. Still, for the price and for the effects, this stuff is a steal
when compared with using 2iu of GH every day.
One of my powerlifter friends (read: Lab Rats), who assists me in some of my
research used Hexarelin while training for a meet. He had the dual purpose of
rehabbing a shoulder as well as trying to increase his bench press. As you
probably could have guessed, his bench went up, and his shoulder seemed to have
healed. He was using roughly half the dose of Hexarelin I recommend for
hypertrophy and fat loss, which worked out to about 50mcg/day shot 2x a day in
the injured shoulder. His shoulder healed up nicely, and his strength went up a
bit. Neither myself nor my friend had any increased appetite on Hexarelin, and I
suspect that this is because it has a much less profound effect on Ghrelin
levels. The strength gains we both received from its use were very similar to
those experienced with GHRP-6, but with very little weight gain, and negligible
fat loss. Hexarelin is a nice addition to a cutting cycle, to make maximum use
of the GH response to both anabolic steroids as well as!
the GH induced response from training. And, it never hurts to include
something that???s going to help your joints on a cutting cycle, since we know
that the typical compounds used in a cutting cycle (Winstrol, etc???) often
cause joint problems. We can use the added GH from the Hexarelin to help protect
our otherwise compromised joints on a cycle, without spending tons of money on
Unlike GH, however, some attenuation to Hexarelin occurs by week 4, and
continues on up to 16 weeks of use. By separating Hexarelin cycles by 4 week off
periods, this attenuation can be totally reset, (9) and the next cycle of
Hexarelin will produce the same level of results as the first cycle. During a
cutting cycle, I recommend using Hexarelin for the weeks where compounds such as
Winstrol are used, and continuing its use for the duration of the cycle. If
you???re using Lr3IGF-1 on your cutting cycle, then I recommend saving the
Hexarelin for after the IGF use is over.
Although, many athletes use Hexarelin alone, others have used it after a Growth
Hormone or Insulin-Like Growth Factor one cycle, to as a form of Post-Cycle
Therapy for the recovery of their own natural GH and IGF-1 production. Again,
for this purpose, 2mg/kg, injected subcutaneously is the proper dose per day.
Although they???re new, and haven???t been experimented with too extensively in
the bodybuilding community, I think that both GHRP-6 and Hexarelin will be used
more commonly in the coming months and years. It took me far too long to jump on
the bandwagon with IGF, and I was far too slow to begin my personal
experimentation with MGF, so when these two peptides became available to me, I
didn???t want to let the opportunity go for too long. Now, after some pretty
extensive personal experimentation with these two peptides, I think that
Hexarelin is a great anabolic addition to a cutting cycle, and GHRP-6 is
probably the most potent (non-steroid) weight gainer that I???ve ever used.
Considering the price, legal status, and availability, these two are probably
going to find their way into quite a few cycles over the next few years.
1. Cheng K, Chan WW-S, Butler BS, Barreto A, Smith RG 1989 The synergistic
effects of His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 on GRF stimulated growth hormone
release and intracellular cAMP accumulation in rat primary pituitary cell
cultures. Endocrinology 124:2791???2797
2. Smith RG, Pong S-S, Hickey GJ, Jacks TM, Cheng K, Leonard RJ, Cohen CJ, Arena
JP, Chang CH, Drisko JE, Wyvratt Jr MJ, Fisher MH, Nargund RP, Patchett AA 1996
Modulation of pulsatile GH release through a novel receptor in hypothalamus and
pituitary gland. Recent Prog Horm Res 51:261???286
3. Leonard RJ, Chaung L-YP, Pong S-S 1991 Ionic conductances of identified rat
somatotroph cells studies by perforated patch recording are modulated by growth
hormone secretagogues. Biophys J 59:254
4. Smith, Development of Growth Hormone Secretaogues, Endocrine Reviews, 26(3)
5. Ghrelin: structure and function. Physiol Rev. 2005 Apr;85(2):495-522. Review.
6. Penlava, A, et. al. Effect of growth hormone ( GH)-releasing hormone (GHRH),
atropine, pyridostigmine, or hypoglycemia on GHRP-6-induced GH secretion in
man.J Clin Endocrinol Metab. 1993 Jan;76(1):168-71.
7. Imbimbo, B.P., et. al Growth hormone-releasing activity of hexarelin in
humans. A dose-response study.Eur J Clin Pharmacol. 1994;46(5):421-5.
PMID: 7957536 [PubMed - indexed for MEDLINE]
8. Kinetics and Disposition of Hexarelin, A Peptidic Growth Hormone
Secretagogue, in Rats
Marie Roumi, Sylvie Marleau, Patrick du Souich, Tony Maggi, Romano Deghenghi,
and Huy Ong
Drug Metab. Dispos., Jan 2000; 28: 44.
9. Rahim, A., Shalet, SM Does desensitization to hexarelin occur?
Growth Horm IGF Res. 1998 Apr;8 Suppl B:141-3.