I’ll try to keep this as short as I can because I feel like this is a very new topic - reviewed in May 2019 and published on June 4th, 2019 - of course warranting further exploration and discussion. I’m hoping that some of this site’s contributors can add some thoughts to these findings.
It appears that “extra” glucose tolerance is a recently acquired trait (500-50k years according to the study) just like Lactose tolerance was acquired, and that this tolerance has spread to some populations but not all races obv. In fact, SNPedia here lists massive differences from one region to another.
What I’m getting at is that I’m a type 1A. I’ve had HbA1c up to 6.2% while at my peak physique, embracing the frequent carb meals life. Turns out that I’m part of the 18% Europeans who’s also a T,T “hunter gatherer” homozygote. Somewhat unexpected tbh.
What’s Thib’s nutritional recommendations (and they’re spot on for me) = less carbs as in pretty much post workout only, not a whole lot of fat either, tons of protein. Eggs and nuts for breakfast. Multiple snacks, nothing that would push me off the sympathetic mode. This is quite consistent with Ori Hofmekler’s idea of a “Warrior Diet” who’d have the ancient genetics to “trap” glucose in the cell and fast / undereat, then feast - except that humans have evolved a lot, which is to say that neither paleo advocates nor vegans are inherently right or wrong. At least according to this very recent publication. Rhonda Patrick often mentions fructose “ATP trapping” and I think that this isn’t much different.
From there it would seem consistent to view type 2s as “farmer-hunter” heterozygotes maybe? and type 3s as the “farmer” homozygote type?
I think that this place is more open minded than your Reddit’s typical “just do 5x5 and eat whole grains” hive mind - I tried debating the topic on r/nutrition, to no avail . It would be great if there was a correlation between saliva testing and your neurotype.
Hopefully some people who’ve done both can chime in and add their results? If anyone here has done 23andme or ancestry or myheritageDNA testing, the gene you’re looking for should be in the raw data somewhere. Ctrl+F “Rs1061325”