I heard you should not supplement with Glycine if you have high Glutamate and low GABA. According to my DNA, I am homogeneous in several GAD1 SNPs. It says that I have low GAD1 activity and have high glutamate and low GABA.
I have been supplementing with Glycine and Magnesium Glycinate before bed. I haven’t found either to be a problem and the magnesium glycinate has actually been beneficial. I don’t seem to get an effect from Glycine though. I do take them with Taurine, which DEFINITELY has been beneficial to me. Tryptophan is very helpful as well.
In the past I have also supplemented with GABA directly. Sometimes it would work, other times it caused anxiety
So are those genetic tests reliable? Additionally I am a Type 3 in the neurotyping system.