I was at a new year's eve party a few years back with I think one of my friends and a bunch of people I didn't know too well. This friend can be a little abrasive sometimes (ok, most of the time) if you let him get to you, for the most part I just think he's funny.
Anyways, he's talking with this girl who takes something the wrong way and feeds him a pretty sharp insult. He responds with something to the effect of "Whoa, easy there, what's wrong with you, you think these muscles protect me from insults? They don't help at all! Tell her Jonty!"
And I says "Muscles are like a bad sweater, the emotional wind cuts right through'em."
Probably not the funniest thing I've ever said but it sticks out in my memory as getting one of the best reactions.