finasteride syndrome is characterized as an induced case of secondary hypogonadism and you fit that exactly with low LH/FSH. However, you may have been somewhat secondary prior to finasteride.
Your FT levels are low so FT-->E2 production is low. E2=25 may be indicating impair E2 clearance in the liver. Some of your meds, Rx or OTC might be doing this and AD meds have been known to. In any case, your low FT with E2=25 makes you significantly estrogen dominant and that is part of your symptoms.
SHBG is low. So less T is bound in non-bioavailable SHBG+T.
Your T levels are low, but a 64% is bio-available because of low SHBG.
Some guys simply have low SHBG. But low SHBG is also seen with low insulin sensitivity or diabetes. Your fasting glucose or A1C labs would be of interest.
Labs if available:
- fasting glucose
- fasting cholesterol
- prolactin - can reduce LH/FSH
Where are you located? Affects diagnostic and treatment options.
Your sex hormones can easily be major players in you mood/depression.
- TSH is low a bit.
- FT3 is below 3.5 midrange
- FT4 is below mid-range
- A bit of an odd combination. I need your history of using iodized salt and/or vitamins listing iodine. Also need you to provide both of the body temperatures as per the last paragraph in this post.
Looking back over the years:
Was libido strong once and when did that start slipping away?
Does body/facial hair suggest that you were well virilized years ago?
Loss of hair below the knees is from long term low-T.
I think that you should go after TRT with all of the energy you can muster.
If your testes are perfectly normal, you might be able to use hCG alone, otherwise after a trial, self-injected T is your best bet.
We also need a conversation about your needs to preserve fertility.
Please read the stickies found here: https://forums.t-nation.com/t/about-the-t-replacement-category/38/2?u=ksman
- advice for new guys - need more info about you
- things that damage your hormones
- protocol for injections
- finding a TRT doc
Evaluate your overall thyroid function by checking oral body temperatures as per the thyroid basics sticky. Thyroid hormone fT3 is what gets the job done and it regulates mitochondrial activity, the source of ATP which is the universal currency of cellular energy. This is part of the body's temperature control loop. This can get messed up if you are iodine deficient. In many countries, you need to be using iodized salt. Other countries add iodine to dairy or bread.