It’s useful because males don’t want their Estrogen levels to get too high!
Why it Matters
There are basically two very important reasons that we need to care about Estradiol.
The first is that Estradiol is a powerful Testosterone receptor antagonist. What this means to us men is that Estradiol creates a very strong bond to the Androgen Receptors of Testosterone and renders them useless.
However, when testosterone binds to an Androgen Receptor, it activates that receptor and we get the physiological effects we’re all looking for. Now, when Estradiol binds to that same receptor it blocks Testosterone from binding, yet it does not activate the receptor, so in short nothing happens.
This means that if your Estradiol serum level is high, no matter how much exogenous testosterone you take it isn’t going to help you as it should because too many of your androgen receptors are now blocked by Estradiol and your Free Testosterone has nowhere to go.
Exogenous Testosterone can’t do you any good if it doesn’t have receptors available to activate?simple enough.
Now, things can get worse believe it or not… some believe that elevated levels of Estradiol can cause the down regulation of Androgen Receptors. What this potentially means is that your body may respond to higher levels of Estradiol by creating fewer Androgen Receptors as cells are replaced in a normal regeneration cycle .
So, not only does Estradiol block the available Androgen Receptors as noted, it may cause your body to produce fewer of them in the future!
This is where many Docs get it wrong and is one primary reason why just ?raising Testosterone serum levels? alone as a mono-therapy may not have any immediate effect on a man. It may be that the receptors have been down regulated and so there will be a need to lower Estradiol levels and increase Testosterone levels in order to get a man?s body to up-regulate again and this could take some time.
The second reason we care about Estradiol in men is that we also have Estrogen Receptors and Estradiol will bind to them and cause them to activate. This is fine if you want to grow man boobs (Gynocomastia) add belly fat and get an enlarged prostate, among other things, but not so good if you want to look and feel like a healthy man.
Keep in mind, the aromatase enzyme lives in the skin and has a propensity for abdominal fat. Meaning the more belly fat you have the higher level of aromatase you will have.
Why the “Sensitive Assay” test is vital for males:
In Dr. John Crisler’s own words, and he’s probably the leading expert in the field of HRT/TRT…
"A word about Estradiol ?Sensitive? Testing
Unless your Doctor specifically requests a ?Sensitive? assay the lab will default to the standard Estradiol assay designed specifically for women, which is useless for men. The reason for the difference between the two assays is the bell curve from which the test was designed sits within the ?normal? range for women and not men.
Therefore, the hormone concentration range appropriate for adult men falls on the flat slope of that bell curve making it completely inaccurate for testing men?s E2 serum levels. Always, ask for the ?Sensitive? assay when your Doctor is conducting a blood test and testing for Estradiol."
He goes on to say that a reading from the “standard” Estradiol test could show much higher levels of Estradiol/Estrogen than the patient actually has…"
Which could lead to the unnecessary prescribing of a very powerful aromatase inhibitor such as Arimidex/Anastrozole when it actually isn’t even necessary.
Hope this helps.
Excellent points.I read that in regards to Neuroreceptor’s,Androgenrecetor’s etc. The cells i.e. receptor sites live for a period of time,similar to telemers the dna strand,it gets shorter as we age and or abuse it.Scientists have different opinions on receptors and there self life.Also muscle building.People believe it’s causes by breaking down and rebuilding.The other camp thinks it’s a result of new satellite cells being developed,hence new muscle tissue. have a good day john