How is that working for you?
Collectively, we have a better handle on TRT than almost all docs.
Your E2 was expected to be a problem, but is staggeringly so.
So your moodiness would be persistent.
AST/ALT does not suggest a liver problem increasing E2.
But note that some meds, Rx and OTC can reduce E2 clearance in the liver.
You should feel vastly better getting near E2=22pg/ml. Results of a anastrozole dose or dose change take around one week to feel. Mood, libido and energy will change.
HTC is a mess as I suggested as a possible outcome.
Avoid iron fortified foods, breads, pasta etc and men should not have iron in their vitamins.
With lower E2, body fat and fat patterns should change.
We do see some guys who freely convert DHEA-->E2 in the adrenal glands. There are many variations in genetic code that code for enzymes and I expect that this is a cause of this effect. 50mg DHEA is often more than needed. Try 25mg/day and test DHEA-S again later.
Reducing DHEA and anastrozole will both effect E2. Thus, changes to DHEA intake may change anastrozole dosing needs.
What was iodine intake at this time? Or how long since high dose iodine.