There’s lots of things that can increase dopamine levels. Browsing around wikipedia should yield lots of information. There’s dopamine agonists, dopamine reuptake inhibitors, dopaminergenic analogues & precursors, etc.
Wellbutrin has a very slight dopamine reuptake inhibition. More so than other antidepressants, yet research shows its dopamine reuptake inhibition is FAR less significant than we think. Like someone else said, people respond differently to it. So even if your bro has a dopamine deficiency, Wellbutrin may not be not be key. Other pharmas that work on dopamine: methylphenidate, dextroamphetamine, selignine, pramixepole, etc. The first two you may know as ritalin and adderall, which are used for ADHD; the latter two are drugs given to patients with parkinson’s disease. All four are used (though not necessarily popularly) by docs for treatment resistant depression.
A good question to ask your friend is what sort of recreational drugs does he prefer: alcohol, mary jane, uppers, or downers. Uppers - cocaine, methamphetamine, amphetamine, mdma, etc - generally work by inhibiting dopamine reuptake and also pumping out “dormant” dopamine in your nervous system. So if he prefers uppers, it’s a pretty good indicator IMO that he maybe lacks the “normal” levels of dopamine.
There’s natural supplements that can help. Go to mindandmuscle.net and look at the nootropic forum and some of the articles. There’s stuff called PEA, L-Dopa, L-Tyrosine, and a bunch of others, all of which are used by the body during the synthesis of dopamine. Some people report great results with these substances. Also, it’s important although cliche that a good diet is being followed. The body needs its full spectrum of nutrients, vitamins, minerals, etc. for healthy neurotransmitter production.
I’d like to say something to the scientologists who have posted above saying “it’s all in his head:” unfortunately, it’s not. Millions of pages of scientific studies support the fact that as a result of genetics some people’s brains don’t function “regularly” in regards to the biochemistry. An analogy: some people suffer from hormone deficiency and require HRT to maintain stable testosterone levels. They were born this way. The same goes for people’s brain chemistry: some people are born with genes that tell the body to not do what is normal. For all of Big Pharma’s flaws, they do serve an important function: they help more people than they hurt.
That being said, his depression is very likely biochemically-originated, but because he’s been living with it so long it is also behavioral. The right prescription pharmaceutical will help, but it’s also imperative that he seeks counseling (likely cognitive behavioral therapy) to help him psychologically as well. These two go hand in hand: you need a healthy brain for counseling to work, and you need counseling to help you adjust to your “new” brain!
Probably the best thing you can do for your friend is sit him down tell him you hate seeing him like this (reminds me of Pantera’s song, Hollow) and that you want to help him to “be happy.” It’s a long process, but in the end, it may very well be the most generous, selfless thing anyone’s ever done for him!
Hope this helps!
Cheers for typing that out man !
I got him to go to his Doctor yesterday he was prescribed Zyban European Wllbutrin ?
So on his 2nd day now, here’s hoping.
We can get can L-Tyrosine in the health shops is that good enough ?
I’ll look for the other 2, PEA, L-Dopa again cheers for the info from you and all, most appreciated,