2006 Tour de France Champion Floyd Landis was found to have an abnormal testosterone-to-epitestosterone ratio. What does that exactly mean? Is it possible to have an “abnormal” level through legal means - Biotest supps, etc? Is that ratio the definitive way to test for doping, or is the media blinded by ignorance?
The public is sure quick to point an accusatory finger at Landis, but I have my doubt as to the guilt of Landis. Some scientific clarification would be appreciated.[/quote]
I’ll link a great paper that you can read on the subject.
As for your question about having a higher T/E ratio from the Biotest supplements or any compounds which increase endogenous testosterone, the answer is no.
The T/E ratio is effective but has its own flaws. There have been a number of case reports indicating false positives and a small percentage of the population may naturally have a T/E ratio higher than 6. Various research groups have investigated alternative methods which have some advantages, but despite this, I continue to see the T/E ratio used in most cases. The paper I’ve linked includes one alternative method, the T/LH ratio.
Is there a chance he could be part of the population that has a naturally occurring T/E ratio higher than 6? Certainly. However, the probability isn’t exceptionally high.
As a side note, this paper also has some good kinetic data for testosterone cypionate for those interested, namely the elimination half-life.