You may also want to read up on pomegranate.
While I saw reports talking about prostate cancer specifically, it also seems to be implicated in a lot of general health benefits… which to me may imply some type of fundamental impact.
This, from the LEF, may also be interesting…
Cimetidine (Tagamet?) is an over-the-counter ulcer medication that has beneficial effects in treating colorectal cancer and improving survival. Cimetidine prevents cancer growth and spread by several different mechanisms, including enhancing the immune response via stimulation of natural killer (NK) cells and interleukin-2 (IL-2) production, preventing histamine activity and thus immunosuppression, and reducing cancer-cell adhesion molecule expression (Tang NH et al 2004; Kubota T et al 2002; Kobayashi K et al 2000).
Colorectal cancers secrete histamine in high concentrations, enough to be locally immunosuppressive (Reynolds JL et al 1997; Melmon KL et al 1972). Histamine?s suppression of the immune response (immunosuppression) prevents the body from mounting a desirable attack against the tumor (Rocklin RE et al 1979). Cimetidine helps restore natural killer cells (Bai D et al 1999) and thus prevents this immune suppression (Adams et al 1993,1994a,b; Hansbrough JF et al 1986), resulting in prolonged survival of patients who undergo colorectal cancer surgery (Matsumoto S et al 2002).
In just seven days of treatment with 800 mg of cimetidine twice daily (Kelly MD et al 1999)?five days prior to surgery and two days post-surgery?the three-year mortality rate decreased from 41 percent to 7 percent in colorectal cancer patients (Tavani A et al 1998; Uchida A et al 1993). Furthermore, cimetidine improves survival in patients with noncurative surgery for stage IV colorectal cancer (Yoshimatsu K et al 2003). Indeed, cimetidine used in conjunction with chemotherapy can significantly improve survival rates. Patients with aggressive colon cancer had a remarkable 84.6 percent 10-year survival rate when treated with cimetidine (800 mg per day) together with 200 mg per day of 5-fluorouracil (5-FU) for one year starting two weeks after surgery, compared to a 49.8 percent 10-year survival rate for patients who were not treated with cimetidine as an adjuvant therapy (Matsumoto S et al 2002). Patients who had tumors with high expression of the Lewis antigen and were treated with cimetidine had a 10-year cumulative survival rate of 95.5 percent compared to 35.1 percent for those who had tumors with low expression of the Lewis antigens (Matsumoto S et al 2002).
The FDA, however, has not approved cimetidine for use in cancer treatment, which means that colorectal cancer patients should discuss the off-label use of cimetidine with their treating physician. While cimetidine can be purchased over the counter, it may be covered by insurance if prescribed by a physician.
Also, the LEF site talked about eating fried red meat being something that is associated with increased colorectal cancer risk. It might make sense to avoid that and other things that are identified as risk factors, so as not to stress pathways that may already be compromised.
Here’s the page I was reading from… plenty of reading… and decisions whether or not various things might be applicable or helpful.