T Nation

Finasteride and T Replacement


#1

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#2

T–>DHT via 5-alpha reductase enzyme. You can use low dose finasteride to modulate DHT and not DHT–>zero.

You have hair loss genetics. Your case suggests that your T levels were always a bit low.

Transdermal T, T gels etc, create the highest DHT levels. Peaks from injections also are probably a problem. Self-injecting smaller doses twice a week would be best, but probably you cannot do that there. T injected every few months will lead to high DHT levels at times.

Please read the stickies found here: About the T Replacement Category

  • advice for new guys - need more info about you
  • things that damage your hormones
  • protocol for injections
  • finding a TRT doc

Evaluate your overall thyroid function by checking oral body temperatures as per the thyroid basics sticky. Thyroid hormone fT3 is what gets the job done and it regulates mitochondrial activity, the source of ATP which is the universal currency of cellular energy. This is part of the body’s temperature control loop. This can get messed up if you are iodine deficient. In many countries, you need to be using iodized salt. Other countries add iodine to dairy or bread.


#3

Can you tell me how you came up with that theory? What’s the science behind that?


#4

Because if his T levels were optimally higher at a younger age he would have lost the hair earlier in life, now that his T is higher now he’s losing more hair. My brother lost his hair at 30 years old do to high T levels and high DHT, his genes makes him sensitive to high DHT. Even multiple trips to Bosley provided limited results.


#5

I have reason to believe there is truth to your statement I just haven’t seen anyone state it before. I was hoping you had something more to point to other than common sense. It makes sense that lower T and DHT at younger ages followed by TRT and higher DHT later in life can lead to hair loss since the new normal level of DHT will be above a certain biological threshold and now at a level higher than the hair follicles can tolerate. However I don’t agree with => “Because if his T levels were optimally higher at a younger age he would have lost the hair earlier in life,” - Lots of guys have high T and DHT throughout life and don’t lose their hair.

I believe there is a sensitivity threshold for everyone. If your brother’s sensitivity level was 60 and he ran 70+ his whole life then that would explain DHT related hairloss - but I suspect he would look to other family members to easily see what his hair will look like in 20 years. If one guy in a family loses his hair and the brothers and father do not then there is something specific to that individual that he caused to happen. Comments made by docs about how hair loss on TRT only speeds up hair loss you otherwise would have lost; I call BS on that. Again just look to other family members and if you are outlier with hair loss then you did something that the other didn’t do to cause it; like start TRT and spike you DHT above your sensitivity threshold.

As far as the OP - he didn’t report back in May. Trying to up the Fin and then up the Test to keep canceling each other out not reasonable. Stated he has “very little” hair left; shave and move on.


#6

The problem is I bet a lot of guys are above where they would naturally be if it weren’t for TRT, a lot of guys are put on at least 100mg weekly, some higher. The problem unless you got your T checked when you were in your prime you’ll never know where you were naturally. The majority of guys on TRT end up in the 700-1000 range likely higher than natural, you forget about the genetic component that is triggered at a specific age. My brother has had naturally high T levels his whole life and didn’t start losing his hair till the age of 30. Most men start to lose a little hair in their 40’s and 50’s, everyone will lose some hair at some point in their life. I have 3 other siblings and no one else has lost as much hair as my brother or looks quite as old for their age.


#7

No doubt most TRT will take guys above their youthful levels. But you have guys like jay cutler who must have virtually no sensitivity to DHT. Also some guys in 50s and 60s on TRT running DHT around 130 and they claim no hair loss. Lucky bstrds. I have parents in 80s with full heavy head of hair including their siblings and their cousins and all have zero hair loss in family. I started TRT at 140mg/week and massive hair loss DHT went from 41-103 never had previous hair loss. Drop to 100mg/wk and now have light hair loss haven’t had new labs yet. Sounds like maybe your brother has done something or lived a lifestyle different from the others to cause this? I am just not getting the benefits from 100mg/wk to stay on it. Plus I am apparently a high aromatizer went from 18-60 and bad symptoms hot flashes libido crashed and doc is stingy with the anastrazol. TRT might not be for me.


#8

I would shave the head if it meant feeling like I was in my 20’s again versus feeling like pure crap, what good is hair if you feel like sh*T? I’m starting to think my mother had an affair with the mailman when my father was away on business, it’s the only thing that could explain my brother!


#9

yeah i didn’t want to say it.